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Hot spot detection software tools | Protein structure data analysis

Hot spot detection software tools | Protein structure data analysis

Most molecular and cellular processes are controlled by protein–protein interactions. Proteins interact through interfaces. The energy distribution along the interface region is not homogenous; certain residues contribute more to the binding free energy, called ‘hot spots’ (Bogan and Thorn, 1998; Clackson and Wells, 1995; Wells, 1991). Source text: Tuncbag et al., 2010.

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