Provides standardized information on the small disulfide-rich proteins with a knotted topology. KNOTTIN concentrates sequences, structures and bibliographical data about inhibitor cystine knots (ICKs). This database is valuable given the specific properties of these miniproteins in terms of sequence, structure and function. It contains more than 3000 sequences of knottins. This web server also provides a user-friendly access to users’ knottin-specific tools.
A database of proteins with topological links. LinkProt collects information about protein chains and complexes that form links. LinkProt detects deterministic links (with loops closed by cysteine), and determines likelihood of formation of links in networks of protein chains called MacroLinks. Links are presented graphically in an intuitive way, using tools that involves surfaces of minimal area spanned on closed loops. The database presents extensive information about biological functions of proteins with links and enables users to analyze new structures.
Collects information about proteins with knots or slipknots. The knotting complexity of proteins is presented in the form of a matrix diagram that shows users the knot type of the entire polypeptide chain and of each of its subchains. The database presents extensive information about the biological function of proteins with non-trivial knotting and enables users to analyze new structures.