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Knotted proteins are more commonly observed in recent years due to the enormously growing number of structures in the Protein Data Bank (PDB). Studies show that the knot regions contribute to both ligand binding and enzyme activity in proteins such as the chromophore-binding domain of phytochrome, ketol-acid reductoisomerase or SpoU methyltransferase.
(Lai et al., 2007) pKNOT: the protein KNOT web server. Nucleic Acids Res.