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Protein loops are often responsible for functional specificity of a given protein by contributing to recognition of interaction partners, enzymatic reactions with substrates or conformational changes relevant to function. The special properties of protein loops originate from the variable loop structures that occur as a result of substitutions, insertions or deletions in sequence during evolution.
(Ko et al., 2011) The FALC-Loop web server for protein loop modeling. Nucleic Acids Res.