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It has been estimated that 30–40% of proteins require one or more metal ions to be able to carry out their biological function in cells (Andreini et al., 2009; Andreini et al., 2008). This proportion depends on the specific organism or tissue under consideration, which affects also the relative usage of the various metals. Additionally, metal ions play a decisive role in stabilizing the structure of nucleic acids (Pechlaner and Sigel, 2012).
(Andreini et al., 2013) MetalPDB: a database of metal sites in biological macromolecular structures. Nucleic Acids Res.