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Systems biology research is like solving a puzzle: the goal is to figure out how the various parts interact and work together. The interactome of an organism is then analogous to the puzzle’s key: it describes the network of all the protein–protein interactions (PPIs). As such, identifying all the PPIs for an organism is of great value. Despite the use of high-throughput techniques in discovering PPIs, however, the coverage of experimentally determined PPI data remains poor. Such low coverage is partly because the set of possible PPIs to be verified is so large that any exhaustive experimental verification will take a long time, even with high-throughput techniques.
(Singh et al., 2010) Struct2Net: a web service to predict protein-protein interactions using a structure-based approach. Nucleic Acids Res.