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Recombinant protein technology is essential for conducting protein science and using proteins as materials in pharmaceutical or industrial applications. Although obtaining soluble proteins is still a major experimental obstacle, knowledge about protein expression/solubility under standard conditions may increase the efficiency and reduce the cost of proteomics studies.
(Hirose and Noguchi, 2013) ESPRESSO: a system for estimating protein expression and solubility in protein expression systems. Proteomics.