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Structural motifs are important for the integrity of a protein fold and can be employed to design and rationalize protein engineering and folding experiments. Such conserved segments represent the conserved core of a family or superfamily and can be crucial for the recognition of potential new members in sequence and structure databases.
(Pugalenthi et al., 2008) MegaMotifBase: a database of structural motifs in protein families and superfamilies. Nucleic Acids Res.