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Allows prediction of protein-to-protein and phenotype-to-protein functional associations based on phylogenetic profiling. ProtPhylo achieves flexibility and state-of-the-art taxonomic and functional coverage by generating phylogenetic profiles. It concerns more than 9 million non-redundant protein sequences across over 2000 organisms and implements four independent orthology detection algorithms. In summary, this tool allows prediction of subcellular localization, protein domains, membrane spanning regions, and complementary evidence of protein-protein interactions (PPIs).

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ProtPhylo classification

ProtPhylo specifications

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ProtPhylo support



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Gene Center, Ludwig-Maximilians-University, Munich, Bavaria, Germany

Funding source(s)

Supported by the German Research Foundation (DFG) under the Emmy Noether Programme [PE 2053/1-1]; Bavarian Ministry of Sciences, Research and the Arts in the framework of the Bavarian Molecular Biosystems Research Network [D2-F5121.2-10c/4822].

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