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PRSice specifications


Unique identifier OMICS_23656
Name PRSice
Alternative name Polygenic Risk Score software
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages C++
Computer skills Advanced
Version 2.0.14
Stability Beta
Maintained Yes




No version available



  • person_outline Jack Euesden
  • person_outline Paul O’Reilly

Publication for Polygenic Risk Score software

PRSice citations


Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms

PMCID: 5954124
PMID: 29765027
DOI: 10.1038/s41398-018-0144-4
call_split See protocol

[…] Ps, weighted by the log of their association odds ratios (for SCZ, BPD, and college completion) or the beta coefficients (for childhood intelligence) estimated from the discovery GWAS results.We used PRSice v1.23 to calculate the PRSs and test the association between each PRS and the globally impaired ERP group. Associations were tested using logistic regression models including the top 3 principa […]


Individual and shared effects of social environment and polygenic risk scores on adolescent body mass index

Sci Rep
PMCID: 5910407
PMID: 29679049
DOI: 10.1038/s41598-018-24774-5

[…] e results from the largest published meta-analysis of BMI genome-wide association studies. The risk score capturing the most variance in BMI at 11 years old was obtained using the default settings in PRSice, which identifies the most predictive score by high-resolution polygenic risk scoring. Specifically, the risk allele of genetic variants present in both the GIANT 2015 BMI GWAS and the cohort u […]


Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits

Genome Med
PMCID: 5870256
PMID: 29580271
DOI: 10.1186/s13073-018-0532-7
call_split See protocol

[…] We conducted a PRS analysis using PRSice software [] (available at For polygenic profile scoring, we used summary statistics generated from multiple large-scale GWASs of psychiatric disorders and behavioral trait […]


Genetic contribution to ‘theory of mind’ in adolescence

Sci Rep
PMCID: 5823893
PMID: 29472613
DOI: 10.1038/s41598-018-21737-8

[…] urrent cohort.We also investigated if polygenic scores from 6 psychiatric conditions, empathy, cognitive empathy, and cognitive aptitude are associated with performance on the Triangles Task. We used PRSice and investigated the predictive power of polygenic scores at eight different P-value thresholds providing reasonable resolution. We note that the sample sizes for the training GWAS set are vari […]


Data on genetic associations of carotid atherosclerosis markers in Mexican American and European American rheumatoid arthritis subjects

PMCID: 5842364
PMID: 29527544
DOI: 10.1016/j.dib.2018.02.006
call_split See protocol

[…] l/plink/clump.shtml). We used the standard settings (r2 = 0.1 and 250 Kb), which reduced the number of SNPs actually used in the scoring routines from 122,549 to 36,630. This work was performed using PRSice v.1.23, a polygenic risk score software . […]


Integrative genomic analysis of methylphenidate response in attention deficit/hyperactivity disorder

Sci Rep
PMCID: 5789875
PMID: 29382897
DOI: 10.1038/s41598-018-20194-7

[…] We generated polygenic risk scores (PRS) based on the results of the present GWAS using the Polygenic Risk Score software (PRSice). A logistic regression model was applied to test whether PRS at multiple stepwise P-value thresholds (i.e., PT < 1e-04, PT < 1e-03, PT < 0.05, PT < 0.1, PT < 0.2 […]


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PRSice institution(s)
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
PRSice funding source(s)
Supported by an MRC studentship, EU FP7 no. 279227(PsychDPC), and the NIHR Biomedical Research Centre at SLaM and KCL.

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