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PSP specifications


Unique identifier OMICS_02427
Name PSP
Alternative names PhosphoSitePlus, Phosphite
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Content license CC Attribution-NonCommercial-ShareAlike
Maintained Yes


  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
    • Rattus norvegicus

Publications for PhosphoSitePlus

PSP citations


Dissecting Structure Encoded Determinants of Allosteric Cross Talk between Post Translational Modification Sites in the Hsp90 Chaperones

Sci Rep
PMCID: 5932063
PMID: 29720613
DOI: 10.1038/s41598-018-25329-4

[…] To systematically characterize PTM sites in the Hsp90 chaperone proteins, we surveyed PhosphoSitePlus database ( that contains over 330,000 non-redundant PTMs, with 95% of the sites obtained from mass spectrometry experiments. We extracted all PTM sites in t […]


Non canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy

Nat Commun
PMCID: 5931534
PMID: 29717115
DOI: 10.1038/s41467-018-03907-4

[…] ing the Scansite algorithm at high stringency, looking for all potential motifs. Four potential phosphorylation sites were found (Tyr208, Thr265, Ser289, Thr359). Next, this list was crossed with the PhosphoSitePlus database for reported phosphorylation sites on DAPK2. Two sites were found in both lists: Ser289 and Thr359. According to the Scansite algorithm, both Ser289 and Thr359 fit the consens […]


First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos

Sci Rep
PMCID: 5827021
PMID: 29483630
DOI: 10.1038/s41598-018-22069-3

[…] mpare potential cross-talk/interplay between Kcr and other PTMs such as Kac and lysine ubiquitination (Kubi), Kcr results were compared with the results in humans using the Kac and Kubi database from PhosphoSitePlus. Of the total 323 Kcr sites converted to humans except for redundant sites, 95 Kac (29.4%) and 42 Kubi (13.0%) sites were detected in the same lysine residue. Kcr is expected to be inv […]


Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis

Sci Rep
PMCID: 5797227
PMID: 29396449
DOI: 10.1038/s41598-018-20231-5

[…] Next, we searched our data set for the known kinase-substrate relationships annotated in PhosphoSitePlus. Only about 10% of the phosphopeptides (146) from the cytokinesis selective clusters, have at least one known upstream kinase (Supplementary Table ). The most prominent kinases in this […]


Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer

PMCID: 5884642
PMID: 29643987
DOI: 10.18632/oncotarget.24337

[…] uman Integrated Protein-Protein Interaction rEference (HIPPIE) (updated 9/1/2015; []), Human Protein Reference Database (HPRD Release 9; []), Interlogous Interaction Database (I2D version 2.9; [, ]), PhosphoSitePlus ( - downloaded 10/15/2015; []) and Reactome protein-protein interactions (downloaded 12/15/2015; []). Out of the 254 kinases in the MIB data set, 246 were found to have […]


RNF138 mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation induced apoptosis

PMCID: 5799804
PMID: 29371697
DOI: 10.1038/emm.2017.247

[…] rmine which among these Lys are ubiquitination sites, based on the three-dimensional structure of rpS3 (Protein Data Bank ID: 3KC4) and prediction results from the ubiquitination prediction database (PhosphoSitePlus, UbPred, iUbiq-Lys and UbiProber), we mutated six Lys residues (K10, K90, K151, K202, K214 and K227) to Ala and measured radiation-induced poly-ubiquitination (). This analysis reveale […]


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PSP institution(s)
Department of Bioinformatics and Computational Biology, Cell Signaling Technology Inc., Danvers, MA, USA; University of Montana, Missoula, MT, USA
PSP funding source(s)
Supported by National Institutes of Health [R43GM065768, R44AA014848m, R44CA126080 and U54-HL127624-01].

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