Kinetic modeling of complex biochemical systems is central to the emerging field of systems biology. Kinetic models require definition of numerous free parameters, usually obtained by calibration to experimental data, that specify initial species concentrations and kinetic rate constants. Once calibrated, a model should be analyzed for its sensitivity and predictive power over ranges of parameter values. Both model calibration and analysis can require thousands to millions of model simulations for statistical convergence and significance. In many cases, the computational expense of simulation at this scale makes detailed model analysis infeasible.