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QuiXoT specifications


Unique identifier OMICS_21743
Name QuiXoT
Software type Toolkit/Suite
Interface Graphical user interface
Restrictions to use None
Operating system Windows
Programming languages C#
Computer skills Medium
Version 1.5.02
Stability Stable
Maintained Yes




No version available


  • person_outline Jesus Vazquez
  • person_outline Pedro Navarro

Additional information


Publication for QuiXoT

QuiXoT citations


Proteomic footprint of myocardial ischemia/reperfusion injury: Longitudinal study of the at risk and remote regions in the pig model

Sci Rep
PMCID: 5617837
PMID: 28955040
DOI: 10.1038/s41598-017-11985-5

[…] scovery rate (FDR) of peptide identifications was calculated by the refined method,. Quantitative information was extracted from the MS/MS spectra of iTRAQ-labeled peptides using the in-house program QuiXoT, as described. Differential protein expression was analyzed using the WSPP model,, which uses raw quantifications as input data and computes the protein log2-fold changes (FC) expressed in unit […]


Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria

Sci Rep
PMCID: 5566220
PMID: 28827575
DOI: 10.1038/s41598-017-09042-2

[…] ch peptide determined as previously described. Protein quantification from reporter ion intensities and statistical analysis of quantitative data to identify significant proteins were performed using QuiXoT based on a statistical model previously described. In this model protein log2-ratios are expressed in form of the standardized variables, i.e., in units of standard deviation according to their […]


Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria

PMCID: 5362505
PMID: 28152519
DOI: 10.18632/oncotarget.14948

[…] tide samples were analysed by LC-MS/MS in a Q-Exactive mass spectrometer (Thermo Fisher Scientific). Protein quantification from reporter ion intensities and statistical analysis were performed using QuiXoT software. All the significant proteins found in the differential analysis were searched against two EVs databases: Vesiclepedia and EVpedia in order to find previous evidence of their expressio […]


Differential proteomic and oxidative profiles unveil dysfunctional protein import to adipocyte mitochondria in obesity associated aging and diabetes

Redox Biol
PMCID: 5220168
PMID: 28064117
DOI: 10.1016/j.redox.2016.12.013

[…] e was set at p<0.05 in all cases. A 1% peptide FDR threshold was considered. Peptide and protein abundance changes were assessed using the iTRAQ reporter ion intensities retrieved from MS/MS scans by QuiXoT software , as inputs to the WSPP model . This model circumvents the statistical issues reported for protein quantitation from iTRAQ-labeled peptides and, by decomposing the different variance […]


Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain Barré syndrome

PMCID: 5342688
PMID: 27776345
DOI: 10.18632/oncotarget.12789

[…] eptide was assigned only to the best protein proposed by the Proteome Discoverer algorithm. Quantitative information was extracted from MS/MS spectra using a quantitative proteomics software package (QuiXoT) [], and protein abundance changes were analyzed using the Generic Integration Algorithm []. Calculation of statistical weights of each quantitation at the spectrum level was performed accordin […]


The intracellular bacterium Anaplasma phagocytophilum selectively manipulates the levels of vertebrate host proteins in the tick vector Ixodes scapularis

PMCID: 5000436
PMID: 27561965
DOI: 10.1186/s13071-016-1747-3

[…] of each peptide determined as described previously []. Protein quantification from reporter ion intensities and statistical analysis of quantitative data were performed as described previously using QuiXoT [, ]. The intensity of the reporter peaks was used to calculate the fitting weight of each spectrum in the statistical model as described previously []. Outliers at the scan and peptide levels […]


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QuiXoT institution(s)
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC−UAM, Madrid, Spain
QuiXoT funding source(s)
Supported by grants BIO2012-37926 and BIO2015-67580-P from the Spanish Ministry of Economy and Competitiveness and grant PRB2 (IPT13/0001 - ISCIIISGEFI/FEDER, ProteoRed) and RD12/0042/0056 from RIC-Red Temática de Investigación Cooperativa en Salud (RETICS), Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III; by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation, and Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505).

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