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In the past decade, a significant increase in interest in bacterial QS is noticed. The discovery of the QS-mediated virulence factor expression in many clinically relevant pathogens raised the idea of QS antagonist production. Blocking QS is now recognized as a viable approach for the development of novel antibiotics (Chen et al., 2011). Moreover, the increased antimicrobial resistance, due to e.g. the formation of a biofilm in which the micro-organisms are protected against antimicrobial chemotherapy and the immune system of the host, has called the attention to the QS system (Heilmann et al., 2010). Intriguingly, recent evidence indicates chemical communication not only between bacteria of different species but also between bacteria and host as well.
(Wynendaele et al., 2013) Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides. Nucleic Acids Res.
(Chen et al., 2011) A strategy for antagonizing quorum sensing. Mol Cell.
(Heilmann et al., 2010) Cell–Cell Communication and Biofilm Formation in Gram-Positive Bacteria. Bacterial Signaling.