Unlock your biological data
The R-loop is a three-stranded nucleic acid structure that is co-transcriptionally formed RNA–DNA hybrid between a nascent guanine-rich RNA transcript segment and a DNA template whilst leaving the non-template DNA strand in a single-stranded conformation. R-loops lie at the interface of multiple biological processes, including RNA transcription and processing, chromatin interactions, DNA damage, mutagenesis as well as cell proliferation and differentiation.
( Jenjaroenpun et al., 2015) QmRLFS-finder: a model, web server and stand-alone tool for prediction and analysis of R-loop forming sequences. Nuclaic Acids Research.