R-loop forming sequence detection software tools | DNA structure data analysis
The R-loop is a three-stranded nucleic acid structure that is co-transcriptionally formed RNA–DNA hybrid between a nascent guanine-rich RNA transcript segment and a DNA template whilst leaving the non-template DNA strand in a single-stranded conformation. R-loops lie at the interface of multiple biological processes, including RNA transcription and processing, chromatin interactions, DNA damage, mutagenesis as well as cell proliferation and differentiation.
Predicts R-loop Forming Sequences (RLFSs) in nucleic acid sequences based on experimentally supported structural models of RLFSs. This tool identifies and visualizes RLFS coordinates from any natural or artificial DNA or RNA input sequences and creates standards-compliant output files for further annotation and analysis. QmRLFS-finder demonstrates highly accurate predictions of the detected RLFSs, proposing new perspective to further discoveries in R-loop biology, biotechnology and molecular therapy.
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