A protein structure prediction web server for template-based modeling, protein contact prediction and ab initio structure prediction. The server has a strong emphasis on modeling difficult protein targets for which templates cannot be detected. RBO Aleph's unique features are (i) the use of combined evolutionary and physicochemical information to perform residue-residue contact prediction and (ii) leveraging this contact information effectively in conformational space search.
Robotics and Biology Laboratory, Department of Electrical Engineering and Computer Science, Technische Universität Berlin, Berlin, Germany
RBO Aleph funding source(s)
Alexander-von-Humboldt Foundation through an Alexander-von-Humboldt professorship, sponsored by the German Federal Ministry for Education and Research (BMBF); National Institutes of Health [1R01GM076706]