A ubiquitous and fundamental step in high-throughput sequencing analysis is the alignment (mapping) of the generated reads to a reference sequence. To accomplish this task, numerous software tools have been proposed. Source text: Fonseca et al., 2012.

Desktop app
G T A T C G C T A Bowtie Bowtie

Bowtie

An ultrafast, memory-efficient short read aligner. It aligns short DNA…

An ultrafast, memory-efficient short read aligner. It aligns short DNA sequences (reads) to the human genome at a rate of over 25 million 35-bp reads per hour. Bowtie indexes the genome with a…

Desktop app
G T A T C G C T A Burrows-Wheeler… Burrows-Wheeler Aligner

BWA Burrows-Wheeler Aligner

A software package for mapping low-divergent sequences against a large…

A software package for mapping low-divergent sequences against a large reference genome, such as the human genome. It consists of three algorithms: BWA-backtrack, BWA-SW and BWA-MEM. The first…

Desktop app
G T A T C G C T A Mapping and Assembly… Mapping and Assembly with Quality

MAQ Mapping and Assembly with Quality

Builds mapping assemblies from short reads generated by the next-generation…

Builds mapping assemblies from short reads generated by the next-generation sequencing machines. Maq is particularly designed for Illumina-Solexa 1G Genetic Analyzer, and has preliminary functions to…

Desktop app
G T A T C G C T A SOAP3 SOAP3

SOAP3

A GPU-based software for aligning short reads with a reference sequence. SOAP3…

A GPU-based software for aligning short reads with a reference sequence. SOAP3 can find all alignments with k mismatches, where k is chosen from 0 to 3. When compared with its previous version SOAP2,…

Desktop app
G T A T C G C T A mrFAST/mrsFAST mrFAST/mrsFAST

mrFAST/mrsFAST

They are designed to map short reads generated with the Illumina platform to…

They are designed to map short reads generated with the Illumina platform to reference genome assemblies; in a fast and memory-efficient manner.

Desktop app
G T A T C G C T A Sequence Search and… Sequence Search and Alignment by Hashing Algorithm

SSAHA Sequence Search and Alignment by Hashing Algorithm

A pairwise sequence alignment program designed for the efficient mapping of…

A pairwise sequence alignment program designed for the efficient mapping of sequencing reads onto genomic reference sequences. SSAHA reads of most sequencing platforms (ABI-Sanger, Roche 454,…

Desktop app
G T A T C G C T A SOAPaligner/soap2 SOAPaligner/soap2

SOAPaligner/soap2

It is an updated version of SOAP software for short oligonucleotide alignment.

It is an updated version of SOAP software for short oligonucleotide alignment.

Desktop app
G T A T C G C T A Stampy Stampy

Stampy

A package for the mapping of short reads from illumina sequencing machines onto…

A package for the mapping of short reads from illumina sequencing machines onto a reference genome.

Desktop app
G T A T C G C T A GSNAP GSNAP

GSNAP

Aligns both single- and paired-end reads as short as 14 nt and of arbitrarily…

Aligns both single- and paired-end reads as short as 14 nt and of arbitrarily long length. GSNAP can detect short- and long-distance splicing, including interchromosomal splicing, in individual…

Desktop app
G T A T C G C T A Subread Subread

Subread

A toolkit for processing next-gen sequencing data. These programs were also…

A toolkit for processing next-gen sequencing data. These programs were also implemented in Bioconductor R package Rsubread.

Desktop app
G T A T C G C T A NextGenMap NextGenMap

NextGenMap

A read mapper that is more than twice as fast as BWA, while achieving a mapping…

A read mapper that is more than twice as fast as BWA, while achieving a mapping sensitivity similar to Stampy or Bowtie2. NextGenMap aligns reads reliably to a reference genome even when the sequence…

Desktop app
G T A T C G C T A SeqMap SeqMap

SeqMap

A tool for mapping large amount of oligonucleotide to the genome.

A tool for mapping large amount of oligonucleotide to the genome.

Desktop app
G T A T C G C T A BFAST BFAST

BFAST

Facilitates the fast and accurate mapping of short reads to reference…

Facilitates the fast and accurate mapping of short reads to reference sequences. BFAST can align the amount of data needed to fully resequence a human genome, one billion reads, with high sensitivity…

Desktop app
G T A T C G C T A SHRiMP SHRiMP

SHRiMP

A software package for aligning genomic reads against a target genome.

A software package for aligning genomic reads against a target genome.

Desktop app
G T A T C G C T A MOSAIK MOSAIK

MOSAIK

A reference-guided aligner for next-generation sequencing technologies.

A reference-guided aligner for next-generation sequencing technologies.

Desktop app
G T A T C G C T A Periodic Seed Mapping Periodic Seed Mapping

PerM Periodic Seed Mapping

Provides highly efficient mapping solutions for genome-scale mapping projects…

Provides highly efficient mapping solutions for genome-scale mapping projects involving Illumina or SOLiD data. The data structure in PerM requires only 4.5 bytes per base to index the human genome,…

G T A T C G C T A CloudBurst CloudBurst

CloudBurst

A parallel read-mapping algorithm optimized for mapping next-generation…

A parallel read-mapping algorithm optimized for mapping next-generation sequence data to the human genome and other reference genomes, for use in a variety of biological analyses including SNP…

Desktop app
G T A T C G C T A RMAP RMAP

RMAP

It is aimed to map accurately reads from the next-generation sequencing…

It is aimed to map accurately reads from the next-generation sequencing technology.

Desktop app
G T A T C G C T A Isaac Genome… Isaac Genome Alignment Software

Isaac Genome Alignment Software

Whole genome secondary analysis on Illumina sequencing platforms.

Whole genome secondary analysis on Illumina sequencing platforms.

Desktop app
G T A T C G C T A Global Alignment… Global Alignment Short Sequence Search Tool
Desktop app
G T A T C G C T A CUSHAW2 CUSHAW2

CUSHAW2

A fast and parallel gapped read alignment to large genomes, such as the human…

A fast and parallel gapped read alignment to large genomes, such as the human genome.

Desktop app
G T A T C G C T A Genomic… Genomic Next-generation Universal MAPper

GNUMAP Genomic Next-generation Universal MAPper

A program designed to accurately map sequence data obtained from…

A program designed to accurately map sequence data obtained from next-generation sequencing machines (specifically that of Solexa/Illumina) back to a genome of any size.

G T A T C G C T A SEAL SEAL

SEAL

A suite of distributed applications for aligning short DNA reads, and…

A suite of distributed applications for aligning short DNA reads, and manipulating and analyzing short read alignments.

Desktop app
G T A T C G C T A RazerS RazerS

RazerS

A read mapping program with adjustable sensitivity based on counting q-grams.

A read mapping program with adjustable sensitivity based on counting q-grams.

Desktop app
G T A T C G C T A Segemehl Segemehl

Segemehl

A tool to map short sequencer reads to reference genomes.

A tool to map short sequencer reads to reference genomes.

G T A T C G C T A DistMap DistMap

DistMap

A user-friendly pipeline designed to map short reads in a MapReduce framework…

A user-friendly pipeline designed to map short reads in a MapReduce framework on a local Hadoop cluster.

Desktop app
G T A T C G C T A Extended Randomized… Extended Randomized Numerical alignEr

ERNE Extended Randomized Numerical alignEr

A short string alignment package whose goal is to provide an all-inclusive set…

A short string alignment package whose goal is to provide an all-inclusive set of tools to handle short (NGS-like) reads. ERNE 2 (a.k.a. bw-erne) uses the Burrows Wheeler Transformation (BWT) to…

Desktop app
G T A T C G C T A di-base read Fast… di-base read Fast Alignment Search Tool

drFAST di-base read Fast Alignment Search Tool

It is designed to map di-base reads (SOLiD color space reads) to reference…

It is designed to map di-base reads (SOLiD color space reads) to reference genome assemblies.

Desktop app
G T A T C G C T A BarraCUDA BarraCUDA

BarraCUDA

Designed to take advantage of the parallelism of GPU to accelerate the…

Designed to take advantage of the parallelism of GPU to accelerate the alignment of millions of sequencing reads generated by NGS instruments. BarraCUDA can align a paired-end library containing 14…

G T A T C G C T A CloudAligner CloudAligner

CloudAligner

Achieves higher performance, covers most primary features, is more accurate,…

Achieves higher performance, covers most primary features, is more accurate, and has a user-friendly interface. CloudAligner was also designed to be able to deal with long sequences. The performance…

Desktop app
G T A T C G C T A TAPyR TAPyR

TAPyR

An efficient Tool for the local Alignment of Pyrosequencing Reads produced by…

An efficient Tool for the local Alignment of Pyrosequencing Reads produced by the GS FLX (454) Genome Analyzer technology against a reference genome sequence.

Desktop app
G T A T C G C T A SToRM SToRM

SToRM

A software tool primarily proposed for mapping SOLiD reads or Illumina reads to…

A software tool primarily proposed for mapping SOLiD reads or Illumina reads to a reference genome.

Desktop app
G T A T C G C T A COmpressive… COmpressive Readmapping Accelerator

CORA COmpressive Readmapping Accelerator

Achieves substantial runtime improvement through the use of compressive…

Achieves substantial runtime improvement through the use of compressive representation of the reads and a comprehensive homology map of the reference genome, when plugged into existing mapping tools.…

Desktop app
G T A T C G C T A HiLive HiLive

HiLive

Implements a k-mer based alignment strategy. HiLive continuously reads…

Implements a k-mer based alignment strategy. HiLive continuously reads intermediate BCL files produced by Illumina sequencers and then extends initial k-mer matches by increasingly produced data from…

Desktop app
G T A T C G C T A AlignerBoost AlignerBoost

AlignerBoost

A toolkit to estimate mapping quality of ambiguously mapped NGS reads.…

A toolkit to estimate mapping quality of ambiguously mapped NGS reads. AlignerBoost utilizes a Bayesian-based framework, and tests with both simulated and real DNA-seq and RNA-seq datasets at various…

Desktop app
G T A T C G C T A Micro-read… Micro-read substitution-only Fast Alignment…

mrsFAST Micro-read substitution-only Fast Alignment Search Tool

A fast, cache oblivious, SNP-aware aligner that can handle the multi-mapping of…

A fast, cache oblivious, SNP-aware aligner that can handle the multi-mapping of high throughput sequencing reads very efficiently. mrsFAST-Ultra improves mrsFAST, our first cache oblivious read…

Desktop app
G T A T C G C T A SparkBWA SparkBWA

SparkBWA

Exploits the capabilities of a big data technology as Spark to boost the…

Exploits the capabilities of a big data technology as Spark to boost the performance of one of the most widely adopted aligner, the Burrows-Wheeler Aligner (BWA). The design of SparkBWA uses two…

Desktop app
G T A T C G C T A NanoOK NanoOK

NanoOK

Provides comprehensive alignment-based analysis of Nanopore reads through a…

Provides comprehensive alignment-based analysis of Nanopore reads through a simple, easy to use interface. NanoOK generates detailed tabular and graphical output plus an in-depth multi-page PDF…

Desktop app
G T A T C G C T A RNFtools RNFtools

RNFtools

An associate software package for Read Naming Format (RNF), a generic format…

An associate software package for Read Naming Format (RNF), a generic format for naming simulated next-generation sequencing reads. The format aims to remove dependency of evaluation tools of read…

Desktop app
G T A T C G C T A HPG Aligner HPG Aligner

HPG Aligner

Upgrades the sensitivity and the rapidity of a DNA mapping by applying suffix…

Upgrades the sensitivity and the rapidity of a DNA mapping by applying suffix arrays. HPG aligner offers an optimal alternative to deal with long reads by reading directly the gzipped files, saving…

Desktop app
G T A T C G C T A SHape Aligner of… SHape Aligner of non-coding RNA developed by Keio…

SHARAKU SHape Aligner of non-coding RNA developed by Keio University

Aligns two read mapping profiles of next-generation sequencing outputs for…

Aligns two read mapping profiles of next-generation sequencing outputs for non-coding RNAs. SHARAKU incorporates the primary and secondary sequence structures into an alignment of read mapping…

Desktop app
G T A T C G C T A SeqLib SeqLib

SeqLib

Provides a rapid and user-friendly interface to BAM/SAM/CRAM files, global…

Provides a rapid and user-friendly interface to BAM/SAM/CRAM files, global sequence alignment operations and sequence assembly. SeqLib provides a command-line tool for performing combinations of…

Desktop app
G T A T C G C T A Mapping Error… Mapping Error Correction and de novo Assembly Tool

MECAT Mapping Error Correction and de novo Assembly Tool

Employs novel alignment and error correction algorithms that are much more…

Employs novel alignment and error correction algorithms that are much more efficient than the state of art of aligners and error correction tools. MECAT can be used for effectively de novo assembling…

Desktop app
G T A T C G C T A Frame-Pro Frame-Pro

Frame-Pro

A profile homology search tool for PacBio reads. Frame-Pro is a tool using…

A profile homology search tool for PacBio reads. Frame-Pro is a tool using Hidden Markov Model (HMM) and directed acyclic graph to correct the errors in DNA sequencing reads. It can also provide…

Desktop app
G T A T C G C T A ntHash ntHash

ntHash

A hashing algorithm tuned for processing DNA/RNA sequences. ntHash provides a…

A hashing algorithm tuned for processing DNA/RNA sequences. ntHash provides a fast way to compute multiple hash values for a given k-mer, without repeating the whole procedure for each value. To do…

Desktop app
G T A T C G C T A Long Approximate… Long Approximate Matches-based Split Aligner

LAMSA Long Approximate Matches-based Split Aligner

Takes the advantage of the rareness of SVs to implement a specifically designed…

Takes the advantage of the rareness of SVs to implement a specifically designed two-step read-splitting and alignment strategy. LAMSA initially splits the read into relatively long fragments and…

Desktop app
G T A T C G C T A Fast Bayesian Bound Fast Bayesian Bound

FBB Fast Bayesian Bound

A canonical reference to compare RNA-seq alignment results across different…

A canonical reference to compare RNA-seq alignment results across different algorithms. FBB uses quality scores of the reads to align them to a genome of reference. Two theorems are provided to…

Web app
CAP3 CAP3

CAP3

The third generation of the CAP sequence assembly program. The CAP3 program…

The third generation of the CAP sequence assembly program. The CAP3 program includes a number of improvements and new features. The program has a capability to clip 58 and 38 low-quality regions of…

Desktop app
G T A T C G C T A de Bruijn Graph-based… de Bruijn Graph-based Aligner

deBGA de Bruijn Graph-based Aligner

An innovative graph-based seed-and-extension algorithm to align high-throughput…

An innovative graph-based seed-and-extension algorithm to align high-throughput sequencing (HTS) reads to a reference genome that is organized and indexed using a de Bruijn graph. With its…

G T A T C G C T A BALAUR BALAUR

BALAUR

A privacy preserving read mapping technique for hybrid clouds that securely…

A privacy preserving read mapping technique for hybrid clouds that securely outsources a significant portion of the read-mapping task to the public cloud, while being highly competitive with existing…

Desktop app
G T A T C G C T A GPU-copy number… GPU-copy number variation

G-CNV GPU-copy number variation

A graphics processing unit (GPU)-based tool for preparing data to detect copy…

A graphics processing unit (GPU)-based tool for preparing data to detect copy number variations (CNVs) with read-depth methods. G-CNV can be used to (i) filter low-quality sequences, (ii) mask…

Desktop app
G T A T C G C T A Optimal Seed Solver Optimal Seed Solver

OSS Optimal Seed Solver

A dynamic-programming algorithm that finds the optimal seeds of a read, which…

A dynamic-programming algorithm that finds the optimal seeds of a read, which renders the minimum total seed frequency. Seed selection is an important step for pigeonhole based seed-and-extend read…

Desktop app
G T A T C G C T A regional… regional Hashing-based Alignment Tool

rHAT regional Hashing-based Alignment Tool

A seed-and-extension-based read alignment approach specifically designed for…

A seed-and-extension-based read alignment approach specifically designed for noisy long reads. rHAT indexes reference genome by regional hash table (RHT), a hash table-based index which describes the…

Desktop app
G T A T C G C T A ParallEl AligNment… ParallEl AligNment UTility

PEANUT ParallEl AligNment UTility

A highly parallel GPU-based read mapper. By exploiting the massive parallelism…

A highly parallel GPU-based read mapper. By exploiting the massive parallelism of modern graphics processors and a novel index data structure (the q-group index), PEANUT achieves supreme speed…

Desktop app
Web app
G T A T C G C T A Teaser Teaser

Teaser

An analytical framework for benchmarking NGS read mappers. Teaser allows…

An analytical framework for benchmarking NGS read mappers. Teaser allows researchers to identify the optimal mapper, parameter set and mapping quality thresholds for data sets that mimic their real…

G T A T C G C T A BigBWA BigBWA

BigBWA

Uses the Big Data technology Hadoop to boost the performance of the…

Uses the Big Data technology Hadoop to boost the performance of the Burrows-Wheeler Aligner (BWA). Important reductions in the execution times were observed when using this tool. In addition, BigBWA…

Desktop app
G T A T C G C T A Artificial Reference… Artificial Reference Driven Estimation of false…

ARDEN Artificial Reference Driven Estimation of false positives in NGS data

A benchmark that estimates error rates based on real experimental reads and an…

A benchmark that estimates error rates based on real experimental reads and an additionally generated artificial reference genome. ARDEN allows the computation of error rates specifically for a…

Desktop app
G T A T C G C T A Basic Alignment tool… Basic Alignment tool for Mismatches

BatMis Basic Alignment tool for Mismatches

An efficient method to align short reads to a reference allowing k mismatches.…

An efficient method to align short reads to a reference allowing k mismatches. BatMis is a Burrows-Wheeler transformation based aligner that uses a seed and extend approach, and it is an exact…

Desktop app
G T A T C G C T A SeqAlto SeqAlto

SeqAlto

An aligner specifically designed for Illumina reads of length greater or equal…

An aligner specifically designed for Illumina reads of length greater or equal to about 100-bp. It takes advantage of this longer read length to provide fast alignment rates and accurate placement of…

Desktop app
G T A T C G C T A BatAlign BatAlign

BatAlign

An algorithm that integrated two strategies called ‘Reverse-alignment’ and…

An algorithm that integrated two strategies called ‘Reverse-alignment’ and ‘Deep-scan’ to improve the accuracy of read-alignment. BatAlign was able to obtain the highest F-measures in…

Desktop app
G T A T C G C T A BitMapper BitMapper

BitMapper

An efficient reads mappers for short reads of equal length. It is designed to…

An efficient reads mappers for short reads of equal length. It is designed to output all mapping locations for each reads. BitMapper is useful for applications, such as ChIP-seq experiments, CNVs…

Desktop app
G T A T C G C T A Anfo Anfo

Anfo

A mapper in the spirit of Soap/Maq/Bowtie, but its implementation takes more…

A mapper in the spirit of Soap/Maq/Bowtie, but its implementation takes more after BLAST/BLAT. Anfo is most useful for the alignment of sequencing reads where the DNA sequence is somehow modified…

Desktop app
G T A T C G C T A Mapping Iterative… Mapping Iterative Assembler

MIA Mapping Iterative Assembler

The basic idea of this program is to align DNA sequencing fragments (shotgun or…

The basic idea of this program is to align DNA sequencing fragments (shotgun or targeted resequencing) to a reference, then call a consensus. Then the consensus is used as new reference and the…

Desktop app
G T A T C G C T A Arioc Arioc

Arioc

A read aligner that uses GPU-based parallel sort and reduction techniques to…

A read aligner that uses GPU-based parallel sort and reduction techniques to identify high-priority locations where potential alignments may be found. The Arioc pipeline implementation consists of…

Desktop app
G T A T C G C T A MICA-aligner MICA-aligner

MICA-aligner

A short-read aligner designed to fully utilize the computing power of many…

A short-read aligner designed to fully utilize the computing power of many integrated core (MIC). MICA-aligner accepts input reads in FASTA/FASTQ format and outputs alignment results in SAM/BAM…

Desktop app
G T A T C G C T A A Long Fragment… A Long Fragment Aligner/A Long Fragment Aligner

ALFALFA A Long Fragment Aligner/A Long Fragment Aligner

Achieves high performance in accurately mapping long (>500bp) single-end and…

Achieves high performance in accurately mapping long (>500bp) single-end and paired-end reads to gigabase-scale reference genomes, while remaining competitive for mapping shorter (>100bp)…

Desktop app
G T A T C G C T A CUSHAW3 CUSHAW3

CUSHAW3

An open-source parallelized, sensitive and accurate short-read aligner for both…

An open-source parallelized, sensitive and accurate short-read aligner for both base-space and color-space sequences. This aligner is designed based on the well-known seed-and-extend heuristic and…

G T A T C G C T A benchNGS benchNGS

benchNGS

A benchmark to assess biological relevance of programs for reference genome…

A benchmark to assess biological relevance of programs for reference genome alignments has been developed and applied to compare the most popular freely available programs. All programs show similar…

G T A T C G C T A Halvade Halvade

Halvade

A framework that enables sequencing pipelines to be executed in parallel on a…

A framework that enables sequencing pipelines to be executed in parallel on a multi-node and/or multi-core compute infrastructure in a highly efficient manner. As an example, a DNA sequencing…

Desktop app
G T A T C G C T A Yet another read… Yet another read aligner

Yara Yet another read aligner

An exact tool for aligning DNA sequencing reads to reference genomes. Main…

An exact tool for aligning DNA sequencing reads to reference genomes. Main features: exhaustive enumeration of sub-optimal end-to-end alignments under the edit distance; alignment of single-end,…

Desktop app
G T A T C G C T A Automation Automation

Automation

An automated method for aligning nanopore data to a reference through the use…

An automated method for aligning nanopore data to a reference through the use of hidden Markov models. Several features that arise from prior processing steps and from the class of enzyme used can be…

Desktop app
G T A T C G C T A marginAlign marginAlign

marginAlign

The package can be used to align reads to a reference genome and call single…

The package can be used to align reads to a reference genome and call single nucleotide variations (SNVs). It is specifically tailored for Oxford Nanopore Reads. The package comes with two programs:…

Desktop app
G T A T C G C T A GNU Backward Search… GNU Backward Search Aligner

GBSA GNU Backward Search Aligner

An inexact mapping algorithm compatible with any backward search approach.…

An inexact mapping algorithm compatible with any backward search approach. Although not intended as a complete sequence mapping tool, the proposed algorithm could be used as a preprocessing step to…

Desktop app
G T A T C G C T A DIDA DIDA

DIDA

A framework that performs the large-scale alignment tasks by distributing the…

A framework that performs the large-scale alignment tasks by distributing the indexing and alignment stages into smaller subtasks over a cluster of compute nodes. First, the targets are partitioned…

G T A T C G C T A Benchmark Benchmark

Benchmark

A comparison of different NGS read mappers. Detailed performance comparisons of…

A comparison of different NGS read mappers. Detailed performance comparisons of NGS read aligners are provided. Benchmarks only measure specific aspects and may not be used to claim any universal…

Desktop app
G T A T C G C T A BioBloom tools BioBloom tools

BBT BioBloom tools

A Bloom filter-based sequence-screening tool that is faster than BWA, Bowtie 2…

A Bloom filter-based sequence-screening tool that is faster than BWA, Bowtie 2 (popular alignment algorithms) and FACS (a membership query algorithm). BioBloom Tools delivers accuracies comparable…

Desktop app
G T A T C G C T A CGAP-Align CGAP-Align

CGAP-Align

Achieves a performance improvement over BWA without sacrificing recall or…

Achieves a performance improvement over BWA without sacrificing recall or precision. This is accomplished through the use of Suffix Tarray, a novel data structure combining elements of Suffix Array…

Desktop app
G T A T C G C T A ZOOM ZOOM

ZOOM

Zillions of short reads are mapped back to reference genomes, including…

Zillions of short reads are mapped back to reference genomes, including post-analysis at unparalleled in speed, at full sensitivity.

Desktop app
G T A T C G C T A BIMA BIMA

BIMA

A next generation sequencing (NGS) mapping and alignment algorithm customized…

A next generation sequencing (NGS) mapping and alignment algorithm customized to process mate pair library sequencing. Mate Pair sequencing is a comprehensive and cost effective method for detecting…

Desktop app
G T A T C G C T A Basic Local Alignment… Basic Local Alignment with Successive Refinement

BLASR Basic Local Alignment with Successive Refinement

A method for mapping Single Molecule Sequencing (SMS) reads that are thousands…

A method for mapping Single Molecule Sequencing (SMS) reads that are thousands of bases long, with divergence between the read and genome dominated by insertion and deletion error. The method is…

Desktop app
G T A T C G C T A FANSe2 FANSe2

FANSe2

A mapping algorithm which can map a billion reads in hours with ultimate and…

A mapping algorithm which can map a billion reads in hours with ultimate and robust accuracy.

Desktop app
G T A T C G C T A YAHA YAHA

YAHA

A flexible, sensitive and accurate hash-based DNA aligner for relatively long…

A flexible, sensitive and accurate hash-based DNA aligner for relatively long queries that operates in three distinct modes. YAHA uses a directed acyclic graph to find the optimal set of alignments…

Desktop app
G T A T C G C T A BWA-PSSM BWA-PSSM

BWA-PSSM

A probabilistic short read aligner based on the use of position specific…

A probabilistic short read aligner based on the use of position specific scoring matrices (PSSM). Like many of the existing aligners it is fast and sensitive. Unlike most other aligners, however, it…

Desktop app
G T A T C G C T A Hobbes Hobbes

Hobbes

A software package designed for fast and accurate alignment of NGS reads and…

A software package designed for fast and accurate alignment of NGS reads and specialized in identifying all mapping locations of each read.

Desktop app
G T A T C G C T A Torrent Mapping… Torrent Mapping Alignment Program

TMAP Torrent Mapping Alignment Program

Alignment software for short and long nucleotide sequences produced by…

Alignment software for short and long nucleotide sequences produced by next-generation sequencing technologies.

Desktop app
G T A T C G C T A TreQ TreQ

TreQ

A read mapper for high-throughput DNA sequencing reads, in particular one to…

A read mapper for high-throughput DNA sequencing reads, in particular one to several hundred nucleotides in length, and for large edit distance between sequencing read and match in the reference…

Desktop app
G T A T C G C T A VelociMapper VelociMapper

VelociMapper

Our new accelerated alignment tool for mapping data from next-generation DNA…

Our new accelerated alignment tool for mapping data from next-generation DNA sequencing systems.

Desktop app
G T A T C G C T A Wisconsin’s… Wisconsin’s High-throughput Alignment Method

WHAM Wisconsin’s High-throughput Alignment Method

A high-throughput sequence alignment tool developed at University of…

A high-throughput sequence alignment tool developed at University of Wisconsin-Madison.

Desktop app
G T A T C G C T A Scalable Nucleotide… Scalable Nucleotide Alignment Program

SNAP Scalable Nucleotide Alignment Program

A sequence aligner that is 10-100x faster and simultaneously more accurate than…

A sequence aligner that is 10-100x faster and simultaneously more accurate than existing tools like BWA, Bowtie2 and SOAP2.

Desktop app
G T A T C G C T A SMALT SMALT

SMALT

Efficiently aligns DNA sequencing reads with a reference genome. SMALT employs…

Efficiently aligns DNA sequencing reads with a reference genome. SMALT employs a hash index of short words (< 21 nucleotides long), sampled at equidistant steps along the genomic reference…

Desktop app
G T A T C G C T A Parallel Processing… Parallel Processing for NGS Analysis

PPSEQ Parallel Processing for NGS Analysis

A software suite including a scalable hierarchical multitasking parallel…

A software suite including a scalable hierarchical multitasking parallel infrastructure and the classical sequencing algorithms.

Desktop app
G T A T C G C T A PIA PIA

PIA

A prefix indexing and alignment for next-generation sequencing (NGS) for whole…

A prefix indexing and alignment for next-generation sequencing (NGS) for whole human genome.

Desktop app
G T A T C G C T A Hybrid Index based… Hybrid Index based sequence Alignment

HIA Hybrid Index based sequence Alignment

A sequence alignment to align both short and long reads to a reference genome.

A sequence alignment to align both short and long reads to a reference genome.

Desktop app
G T A T C G C T A MPscan MPscan

MPscan

Index free mapping of multiple short reads on a genome.

Index free mapping of multiple short reads on a genome.

Desktop app
G T A T C G C T A Parallel Gapped Read… Parallel Gapped Read Alignment

CUSHAW2-GPU Parallel Gapped Read Alignment

This program (based on CUSHAW2) is designed and optimized for Kepler-based…

This program (based on CUSHAW2) is designed and optimized for Kepler-based GPUs, but still workable on earlier-generation Fermi-based ones.

Desktop app
G T A T C G C T A Batman-Seq Batman-Seq

Batman-Seq

A fast BWT-based short reads mapping tools which uses additional statistical…

A fast BWT-based short reads mapping tools which uses additional statistical method to model error profile of the sequencing experiment.

Desktop app
G T A T C G C T A PEAR PEAR

PEAR

An ultrafast, memory-efficient and highly accurate pair-end read merger.

An ultrafast, memory-efficient and highly accurate pair-end read merger.

Desktop app
G T A T C G C T A Cache ASsisted Hash… Deprecated Cache ASsisted Hash Search with Xor logic

CASHX Cache ASsisted Hash Search with Xor logic

Can be used to parse, map, quantify and manage large quantities of sequence…

Can be used to parse, map, quantify and manage large quantities of sequence data. CASHX is a set of tools that can be used together, or as independent modules on their own. The reference genome…

Desktop app
G T A T C G C T A Flow-space Assisted… Deprecated Flow-space Assisted Alignment Search Tool

FAAST Flow-space Assisted Alignment Search Tool

Provides the possibility to both identify potential homopolymer reading errors…

Provides the possibility to both identify potential homopolymer reading errors in pyroseqencing data as well as providing more accurate alignments with pyrosequencing data. FAAST does not only…

G T A T C G C T A HIVE-hexagon HIVE-hexagon

HIVE-hexagon

Implements novel approaches to exploit both characteristics of sequence space…

Implements novel approaches to exploit both characteristics of sequence space and CPU, RAM and Input/Output (I/O) architecture to quickly compute accurate alignments. Key components of HIVE-hexagon…

Desktop app
G T A T C G C T A MaxSSmap MaxSSmap

MaxSSmap

Background Programs based on hash tables and Burrows-Wheeler are very fast for…

Background Programs based on hash tables and Burrows-Wheeler are very fast for mapping short reads to genomes but have low accuracy in the presence of mismatches and gaps. Such reads can be aligned…

Desktop app
Web app
G T A T C G C T A Rapid Amplicon… Rapid Amplicon Mapping in Codon Space

RAMICS Rapid Amplicon Mapping in Codon Space

A hidden Markov model reference mapper, designed to align coding and non-coding…

A hidden Markov model reference mapper, designed to align coding and non-coding DNA to a reference sequence. By default, RAMICS assumes DNA is coding and Sanger-sequenced. Options allow the user to…

Desktop app
G T A T C G C T A REAL REAL

REAL

An efficient, accurate and consistent tool for aligning short reads obtained…

An efficient, accurate and consistent tool for aligning short reads obtained from next generation sequencing. REAL is based on a new, simple, yet efficient mapping algorithm that can match and…

Curators for Read alignment

  • Laurent Mouchard's avatar image
    Laurent Mouchard
    University of Rouen, LITIS EA…
Advertisements
Join Omic Community

By using OMICtools you acknowledge that you have read and accepted the terms of the end user license agreement.