Unlock your biological data
In the past few years, high-throughput next-generation sequencing technologies have effectively replaced earlier data types for genome-wide studies measuring gene expression changes and discovering genomic/epigenetic variations, and many tools were developed for analyzing such datasets. Simulated data is indispensable for guiding tool development and evaluating tool performance, and therefore it is essential to develop simulation software that can produce next-generation sequencing reads that captures the most essential characteristics of real data.
(Huang et al., 2012) ART: a next-generation sequencing read simulator. Bioinformatics.