rec-BTP statistics

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Citations per year

Number of citations per year for the bioinformatics software tool rec-BTP

Tool usage distribution map

This map represents all the scientific publications referring to rec-BTP per scientific context
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Associated diseases


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rec-BTP specifications


Unique identifier OMICS_06141
Name rec-BTP
Alternative name Binary Tree Partition
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages MATLAB, Python
Computer skills Advanced
Version 1.0
Stability Stable
Maintained Yes




No version available


  • person_outline Benjamin J. Raphael

Publication for Binary Tree Partition

rec-BTP citations


An Improved Binary Differential Evolution Algorithm to Infer Tumor Phylogenetic Trees

Biomed Res Int
PMCID: 5723949
PMID: 29279850
DOI: 10.1155/2017/5482750

[…] of subclones by analyzing the variant allele frequencies. Hajirasouliha et al. [] formulate the problem of constructing the subpopulations of tumor cells from the variant allele frequencies (VAFs) as binary tree partition and present an approximation algorithm to solve the max-BTP problem. El-Kebir et al. [] formulate the problem of reconstructing the clonal evolution of a tumor using SNV as the V […]


Enhancing cancer clonality analysis with integrative genomics

BMC Bioinformatics
PMCID: 4597064
PMID: 26424171
DOI: 10.1186/1471-2105-16-S13-S7

[…] al structure using a binomial expectation maximization based approach (via somatic variant allele frequencies), and was specifically designed to deal with multiple samples from a single tumor sample. Rec-BTP [] casts the problem of uncovering the clonal structure of a single sample, using the variant allele frequencies of somatic mutations, as a combinatorial one. A recursive algorithm using a bin […]


Accelerating precision biology and medicine with computational biology and bioinformatics

Genome Biol
PMCID: 4709972
PMID: 25316263
DOI: 10.1186/s13059-014-0450-y

[…] ells with a rooted binary tree in which the nodes correspond to different populations of tumor cells with a distinctive mutation profile. The edges also represent their ancestral relationships. Their binary tree partition algorithm reduces the intrinsic computational challenge. Quaid Morris (University of Toronto, Canada) presented PhyloSub for modeling the clonal evolutionary pattern of tumors. P […]

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rec-BTP institution(s)
Department of Computer Science, Brown University, Providence, RI, USA; Center for Computational Molecular Biology, Brown University, Providence, RI, USA
rec-BTP funding source(s)
Supported by National Science Foundation CAREER Award (CCF-1053753), the National Institutes of Health (R01HG5690), the Burroughs Wellcome Fund, an Alfred P. Sloan Research Fellowship, and a Natural Sciences and Engineering Research Council of Canada (NSERC) Postdoctoral Fellowship.

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