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Provides information about neuronal membrane properties and neuronal models. NeuronDB is a repository of published research information related to three neuronal membrane properties: voltage gated conductances, neurotransmitter receptors and neurotransmitter substances. The database provides information related to neuronal membrane properties for a fixed set of neurons in specific regions of the brain. The information in the repository is localized to specific neuronal compartments. It interoperates with Cell Centered Data Base (CCDB).
CLICs / CLuster In Conservation
A general tool for genome-wide definition of genomic gene clusters conserved in multiple species. Syntenic orthologs, defined as gene pairs showing conservation of both genomic location and coding sequence, were subjected to a graph theory algorithm for discovering CLICs (clusters in conservation). When applied to ORs in five mammals, including the marsupial opossum, more than 90% of the OR genes were found within a framework of 48 multi-species CLICs, invoking a general conservation of gene order and composition.
ORDB / Olfactory Receptor DataBase
A central repository of olfactory receptor (OR) and olfactory receptor-like gene and protein sequences. ORDB began as a database of vertebrate OR genes and proteins and continues to support sequencing and analysis of these receptors by providing a comprehensive archive with search tools for this expanding family. Because of the associated growth of interest in other CRs, the database has grown over the years to include a broad range of chemosensory genes and proteins, that includes in addition to ORs the taste papilla receptors (TPRs), vomeronasal organ receptors (VNRs), insect olfactory receptors (IORs), Caenorhabditis elegans chemosensory receptors (CeCRs), fungal pheromone receptors (FPRs).
Provides a platform for identifying odorant receptors (ORs) for small molecules and for browsing existing OR-ligand pairs. ODORactor enables the prediction of ORs from the molecular structures of arbitrary chemicals. It permits to verify odorant and to recognize OR. The tool is capable to identify novel odorants and their receptors. It may provide an effective way to decipher olfactory coding and could be a useful server tool for both basic olfaction research in academia and for odorant discovery in industry.
A database for experimental restaints of GPCRs. GPCRRD is designed to systematically collect all experimental restraints (including residue orientation, contact and distance maps) available from the literature and primary GPCR resources using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3D structure modeling and function annotation. The current dataset contains thousands of spatial restraints from mutagenesis, disulfide mapping distances, electron cryo-microscopy and Fourier-transform infrared spectroscopy experiments.
SSFA-GPHR / Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors
Provides information on glycoprotein hormone receptor (GPHR)-related topics. SSFA-GPHR is a database that contains protein sequences, multiple sequence alignments (MSA), protein structures, homology models and data from mutagenesis experiments of glycoprotein hormone receptors GPHRs. A web-application facilitates interactive linkage between unified functional and 3D structural information. It can be useful for exploring and recognizing spatial interrelationships between side-chains and causally-induced malfunctions of proteins.
GPCR NaVa database
Integrates data on natural variants in human GPCRs from online databases, the scientific literature, and patents. Where available, variants contain information on their location in the DNA (and protein sequence), the involved nucleotides (and amino acids), the average frequency of each allele, reported disease associations, and references to public databases and the scientific literature. The GPCR NaVa database aims to facilitate studies into pharmacogenetics, genotype-phenotype, and structure-function relationships of GPCRs.
Contains 3D structural models of 1,026 putative G protein-coupled receptors (GPCRs) in the human genome generated by the GPCR-I-TASSER pipeline. In GPCR-I-TASSER, the GPCR sequences are first threaded through the GPCR template library to identify muliple structure templates by the LOMETS programs. When close homolgous templates are identified, full-length models will be constructed by the I-TASSER based fragment assembly simulations, assisted by a GPCR and membrane specific force field and spatial restraints collected from mutagenesis experiments in GPCR-RD.
Facilitates access to relevant data on G-protein coupled receptors (GPCRs) mutants. tGRAP is a database that provides all papers describing experiments (such as radioligand binding or functional testing) on mutant GPCRs, including splice variants and polymorphisms, have been incorporated into the database. Apart from these data, the database provides detailed information on the amino acids being altered, qualitative information on experiments and experimental conditions, and literature references.
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