Biological membranes constitute a chemical barrier to the environment and are thus the prerequisite for the establishment and maintenance of a controlled intracellular milieu, the cytoplasm. In eukaryotes, membranes are also responsible for the formation of chemically distinct intracellular compartments. The lipid bilayer membranes contain a great diversity of proteins that fulfill different functions and serve as an interface to the environment and between different compartments. Among these membrane proteins are receptors involved in signaling cascades and pathogen defense reactions, enzymes such as the apparatus for cell wall biosynthesis, and transporters responsible for the import and export of solutes and ions and the establishment of electrochemical gradients across membranes, thereby connecting the different metabolic pathways of the cellular compartments and organelles.
A central repository of olfactory receptor (OR) and olfactory receptor-like gene and protein sequences. ORDB began as a database of vertebrate OR genes and proteins and continues to support sequencing and analysis of these receptors by providing a comprehensive archive with search tools for this expanding family. Because of the associated growth of interest in other CRs, the database has grown over the years to include a broad range of chemosensory genes and proteins, that includes in addition to ORs the taste papilla receptors (TPRs), vomeronasal organ receptors (VNRs), insect olfactory receptors (IORs), Caenorhabditis elegans chemosensory receptors (CeCRs), fungal pheromone receptors (FPRs).
A database for experimentally solved GPCR structures. GPCR-EXP is a manually curated database that contains all G protein-coupled receptors that have been solved so far. The database is updated weekly. Each entry contains information of PDB ID, resolution, release date, biological name and literature associated with the GPCR.
Provides information on glycoprotein hormone receptor (GPHR)-related topics. SSFA-GPHR is a database that contains protein sequences, multiple sequence alignments (MSA), protein structures, homology models and data from mutagenesis experiments of glycoprotein hormone receptors GPHRs. A web-application facilitates interactive linkage between unified functional and 3D structural information. It can be useful for exploring and recognizing spatial interrelationships between side-chains and causally-induced malfunctions of proteins.
Provides information about odor molecules. OdorDB is a repository designed for reflecting the functional analysis of olfactory receptors (ORs), namely to identify odorants hat interacted with ORs. The database lists more than 200 odorants, and some of which are known to activate ORs. It allows users to access a list of receptors that have been identified as being associated with an ‘odorant’ listed in OdorMapDB.
A database of 7-transmembrane G-linked receptors (also known as G-protein coupled receptors (GPCR)) entries. 7tmrlist proposes various types of information which can be found in the following WWW servers: GCRDb, GPCRDB, ORDB, NIH, ExPASy, Yale, GRAP.
Provides a platform for identifying odorant receptors (ORs) for small molecules and for browsing existing OR-ligand pairs. ODORactor enables the prediction of ORs from the molecular structures of arbitrary chemicals. It permits to verify odorant and to recognize OR. The tool is capable to identify novel odorants and their receptors. It may provide an effective way to decipher olfactory coding and could be a useful server tool for both basic olfaction research in academia and for odorant discovery in industry.