Characterizes mutations associated with disease and identifies metabolic response signatures caused by exposure to certain drugs. Recon3D is a computational resource including 3D metabolite and protein structure data to investigate molecular mechanisms in human metabolism.
Department of Bioengineering, University of California, San Diego, San Diego, CA, USA; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-Sur-Alzette, Luxembourg; RCSB Protein Data Bank, San Diego Supercomputer Center, University of California, San Diego, CA, USA ; Department of Computer Science, Arizona State University, Tempe, AZ, USA; Applied Bioinformatics Group, Center for Bioinformatics Tübingen (ZBIT), University of Tübingen, Tübingen, Germany; Department of Chemistry and Chemical Biology, Center for Integrative Proteomics Research, Institute for Quantitative Biomedicine, and Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, USA; Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Faculty of Science, University of Leiden, Leiden, The Netherlands; Department of Pediatrics, University of California, San Diego, CA, USA
Recon3D funding source(s)
Supported by the Novo Nordisk Foundation Center for Biosustainability and the Technical University of Denmark (grant number NNF10CC1016517), the National Institutes of Health (grant GM057089) and by the Luxembourg National Research Fund (FNR) through the National Centre of Excellence in Research (NCER) on Parkinson's disease and the ATTRACT programme (FNR/A12/01), by the European Union's Horizon 2020 research and innovation programme under grant agreement No 668738, by the Institutional Strategy of the University of Tübingen (German Research Foundation DFG, ZUK 63), and by Google Inc. (Summer of Code 2016) and by the National Science Foundation (NSF DBI-1338415), the Department of Energy, and the National Institutes of Health (NIGMS and NCI).