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REGB specifications

Information


Unique identifier OMICS_26226
Name REGB
Alternative name Roadmap EpiGenome Browser
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Version 1.19
Maintained Yes

Documentation


Maintainers


  • person_outline Ting Wang
  • person_outline Joseph Costello

Publication for Roadmap EpiGenome Browser

REGB citations

 (10)
library_books

Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH

2017
Sci Rep
PMCID: 5593822
PMID: 28894120
DOI: 10.1038/s41598-017-09552-z

[…] obustness to the above novel findings as the cg06500161-triglycerides association had previously been reported, .The cg14476101 site is located in the first intron of the PHGDH gene. According to the Roadmap Epigenome browser, the site is located in the liver in a region enriched for the posttranslational histone modification H3K27Ac (acetylation of lysine 27 of the H3 histone protein) that is ind […]

library_books

Bioinformatics Study of Structural Patterns in Plant MicroRNA Precursors

2017
Biomed Res Int
PMCID: 5322449
PMID: 28280737
DOI: 10.1155/2017/6783010

[…] ng in S2 sequences of the required length, miRNA vicinity was annotated in each instance. In lower stem, we distinguished regA region in 5′ strand and regD in the opposite strand. Upper stem included regB region in 5′ strand and regC in 3′ strand ().The first analytical step was done using WebLOGO [] and MEME Suite []. WebLOGO tool finds the relative frequency of particular nucleotide type at each […]

library_books

The RegA regulon exhibits variability in response to altered growth conditions and differs markedly between Rhodobacter species

2016
Microb Genom
PMCID: 5359404
PMID: 28348828
DOI: 10.1099/mgen.0.000081

[…] en on RegA-dependent gene expression. A previous study indicated that loss of RegA had an effect on aerobic expression of cytochrome cbb3 oxidase (), which was unexpected as the cognate sensor kinase RegB that phosphorylates RegA is thought to be active only under anaerobic conditions (; , ; ). When assaying the effect that a loss of RegA had on aerobic gene expression, we observed that 40 genes e […]

library_books

An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the South Korean population

2016
Sci Rep
PMCID: 5022012
PMID: 27623749
DOI: 10.1038/srep33043

[…] owed similar effect in KoCAS-2 but not significant.To evaluate the functional significance of the newly discovered intergenic variant (rs10879834), we analyzed epigenetic regulatory effects using the Roadmap Epigenome Browser, clustering the histone H3K4me1 profile of SNP-harboring regions between ATXN7L3B and KCNC2. Compared with the common enrichment of enhancer marks in ATXN7L3B across cell typ […]

library_books

Profiling the reactivity of cyclic C nucleophiles towards electrophilic sulfur in cysteine sulfenic acid† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc02569a Click here for additional data file. Click here for additional data file.

2015
PMCID: 4724439
PMID: 26819701
DOI: 10.1039/c5sc02569a

[…] 2 (Prx2; 108 M–1 s–1) and protein tyrosine phosphatase type 1B (PTP1B; 9 M–1 s–1)., Reversible Cys-SOH formation plays a regulatory role among transcription factors, kinases (EGFR, JAK2, Akt2, IKK-β, RegB, PGKase, L-PYK), phosphatases (PTP1B, YopH, PTEN, Cdc25a, SHP-1 and SHP-2), ion channels, peroxidases and cysteine proteases, human serum albumin (HSA) and many other proteins.– Moreover, aberran […]

library_books

Integrative analysis of 111 reference human epigenomes

2015
Nature
PMCID: 4530010
PMID: 25693563
DOI: 10.1038/nature14248

[…] cells, will be of great utility for interpreting genetic changes associated with complex traits. We make all these epigenomic annotations of GWAS regions publicly searchable and browsable through the Roadmap Epigenome Browser and an updated version of the HaploReg database. […]

Citations

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REGB institution(s)
Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, CA, USA

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