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ResQ specifications

Information


Unique identifier OMICS_13454
Name ResQ
Interface Web user interface
Restrictions to use None
Input data One structure model
Input format PDB
Programming languages Perl
Computer skills Basic
Stability Stable
Source code URL https://zhanglab.ccmb.med.umich.edu/ResQ/download/ResQ.tar.bz2
Maintained Yes

Maintainer


  • person_outline Yang Zhang <>

Publication for ResQ

ResQ citations

 (4)
library_books

Analysis of the Sequences, Structures, and Functions of Product Releasing Enzyme Domains in Fungal Polyketide Synthases

2017
PMCID: 5591372
PMID: 28928723
DOI: 10.3389/fmicb.2017.01685

[…] displayed using vmd (). the lid and loop sequences of te domains were extracted and calibrated with structural information and multiple sequence alignment. the normalized b-factor was predicted in resq (). the te-lid sequences were aligned with mafft (). the cavity volumes and cavity lining residue (clr) sites were analyzed by castp () and caver ()., the evolutionary conservation of amino acid […]

library_books

Attenuation of Phosphorylation dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease causing Mutations at the Transmission Interface*

2016
PMCID: 5290968
PMID: 28003367
DOI: 10.1074/jbc.M116.762633

[…] wt protein (excluding the r region, as it is extremely flexible and can mask the effect of other structured regions of cftr). the b-factor values were generated by an algorithm in i-tasser known as resq which takes into account the changes in local structural assembly along with the sequence and structural profiles, and then these values were normalized based on the z-scores (). interestingly, […]

library_books

Role of Pea Enation Mosaic Virus Coat Protein in the Host Plant and Aphid Vector

2016
PMCID: 5127026
PMID: 27869713
DOI: 10.3390/v8110312

[…] topology of the predicted protein structure is indicated by a tm-score >0.5, while a tm-score of <0.17 implies random similarity. the estimation of the residue-specific quality (rsq) by resq [], using a combination of both template-based assignment and profile-based prediction, was used to support the residue-level quality of the protein structure. a low-quality prediction […]

library_books

A novel approach using C. elegans DNA damage induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries

2016
PMCID: 5081529
PMID: 27786254
DOI: 10.1038/srep36026

[…] primary sequence alignment and evolutionary conservation profiles using the promals3d multiple sequence and structure alignment server. finally, for the predictions of the transmembrane domains, the resq b-factor profile provided a consensus prediction where the secondary structure helices (ss) are depicted as red tubes (), and corroborated with the orientation of protein in membranes (opm) […]


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ResQ institution(s)
School of Mathematical Sciences, Nankai University, Tianjin, China; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA
ResQ funding source(s)
This project was supported by the National Institute of General Medical Sciences (GM083107 and GM084222), National Natural Science Foundation of China (NSFC) Grant (11501306), and Nankai University Start-up Grant (ZB15006103).

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