An accurate and high-resolution atlas of gene expression and gene co-regulation in human retina. We collected 50 high-quality post-mortem human retinas from donors and performed high-coverage RNA-sequencing analysis to yield a comprehensive RefT of the human retina. Moreover, we exploited inter-individual variability in gene expression to infer a gene co-expression network and to predict, via a guilty-by-association approach, photoreceptor-specific expression of 253 genes. This atlas represents a valuable resource for the research community at large and help in better elucidating pathophysiological processes in the human retina.
Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy; Dipartimento Studi Aziendali e Quantitativi (DISAQ), Università degli studi di Napoli ‘Parthenope’, Napoli, Italy; Istituto per le Applicazioni del Calcolo, Consiglio Nazionale delle Ricerca, Napoli, Italy; Fondazione Banca degli Occhi del Veneto, Zelarino (Venice), Italy; Medical Genetics, Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples (NA), Italy; Department Of Chemical, Materials and Industrial Production Engineering, University of Naples ‘Federico II’, Naples, Italy
Retina funding source(s)
Fondazione Telethon [TGM11SB2 and TGM11SB1]; EU FP7 Radiant project