Rhea specifications


Unique identifier OMICS_15349
Name Rhea
Software type Pipeline/Workflow
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License MIT License
Computer skills Advanced
Version 1.6
Stability Stable
Source code URL
Maintained Yes




No version available



  • person_outline Ilias Lagkouvardos

Publications for Rhea

Rhea citations


A Walnut Enriched Diet Affects Gut Microbiome in Healthy Caucasian Subjects: A Randomized, Controlled Trial

PMCID: 5852820
PMID: 29470389
DOI: 10.3390/nu10020244
call_split See protocol

[…] Significant differences based on prevalences between groups are calculated by Fisher exact test. For downstream processing of intermediate files generated by IMNGS, a fully modular R-based pipeline (Rhea) was developed for analysis of microbial profiles []. Statistical significance was set at p ≤ 0.05. Any p-values less than 0.05 are shown. […]


Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women

Sci Rep
PMCID: 5607294
PMID: 28931850
DOI: 10.1038/s41598-017-12109-9

[…] deviation. P-values < 0.05 were regarded as statistically significant. According to data distribution, paired Student’s test was applied to assess mean differences before and after the formula diet. Rhea (v1.0.1-5) was used for analysis of fecal microbiota profiles. The effect of VLCD on OTUs and taxonomic counts was tested using Friedman Rank Test for the analysis of a nonparametric randomized b […]

Rhea institution(s)
ZIEL—Core Facility Microbiome/NGS, Technical University of Munich, Freising, Germany
Rhea funding source(s)
This work was supported by the German Research Foundation (DFG) and the Technical University of Munich (TUM) in the framework of the Open Access Publishing Program.

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