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|Interface||Web user interface|
|Restrictions to use||None|
|License||GNU Lesser General Public License version 3.0|
Publication for RiboSubstrates
Automated design of hammerhead ribozymes and validation by targeting the PABPN1 gene transcript
[…] sound. However, RiboSoft has several advantages: it uses the latest research on target-site accessibility; and it has off-target specificity analysis. Off-target accessibility could be evaluated with RiboSubstrates (), but the design of ribozymes would then require the use of two different tools, which makes automated design more complicated. RiboSoft also has the advantage of allowing specificati […]
Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme
[…] d SOFA-HDV-Rz-APP276, -APP753, -APP756, and -APP885, with cleavage activities of 62%, 36%, 36%, and 71%, respectively. These 4 potential SOFA-HDV ribozymes targeting the APP mRNA were tested with the ribosubstrates online software (http://www.riboclub.org/ribosubstrates). This integrated software searches selected cDNA databases for all of the potential substrates for a given SOFA-HDV ribozyme . […]
Development of an isoform specific gene suppression system: the study of the human Pax 5B transcriptional element
[…] ine in position –1, and no two consecutive pyrimidines in positions –1 and –2 (). Moreover, in order to ensure the substrate specificity of the SOFA-HDV Rz, the sequences targeted were analyzed using RiboSubstrates, an integrated bioinformatics software that enables a search of a cDNA database for all potential substrates for a given ribozyme (). This includes the mRNAs that perfectly match the sp […]
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