Provides comprehensive information of RNA modifications concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, RNA-modifying enzymes and location of modified residues in RNA sequences. MODOMICS simplifies literature searches thanks to records cross-referenced to other databases and to selected key publications. It includes a BLAST search of protein sequences and a PARALIGN search of the collected nucleic acid sequences.
Allows the global investigation of more than 100 RNA modification types and reveals extensive and complex post-transcriptional modifications (PTMs) of RNA. RMBase provides a variety of interfaces and graphic visualizations to facilitate analyses of the massive modification sites in normal tissues and cancer cells. Moreover, this platform assists researchers to discover potential functional roles of RNA modifications hidden in different data.
Assists users in investigating and optimizing methods for reprogramming and differentiation of induced pluripotent stem cells (iPSC). PCBC is a publicly available online collaborative research platform that provides data annotation, documentation, and file provenance. This resource also includes metadata, in vitro and in vivo differentiation, qPCR, RNA-seq, miRNA-seq, copy number variation, and DNA methylation data.
Aims at providing a reference resource combining both next-generation sequencing epigenomic and transcriptomic data and quantitative analysis of epigenetic and transcriptional alternations involved in psychiatric disorders. The current release of PD_NGSAtlas contains 43 methylation profiles and 37 expression profiles detected by MeDIP-seq and RNA-Seq respectively, in peripheral blood and two distinct brain regions of SZ, BP and non-psychiatric control individuals.
Provides a comprehensive listing of post-transcriptionally modified nucleosides from RNA. RNAMDB employs an easy-to-use, searchable interface for obtaining detailed data on the 109 currently known RNA modifications. Each entry provides the chemical structure, common name and symbol, elemental composition and mass, CA registry numbers and index name, phylogenetic source, type of RNA species in which it is found, and references to the first reported structure determination and synthesis. RNAMDB serves as a primary information portal for researchers across the entire spectrum of RNA-related research.
Collects methylated RNA immunoprecipitation sequence (MeRIP-seq) samples. MeT-DB is an online database that assists in discovering the unrecognized regulatory roles of N6-methyladenosine (m6A) and foster the further development of bioinformatics tools for methyltranscriptome research. Its interface contains several tabs: (1) browse, (2) statistics, (3) download, (4) FAQ, and (5) references.
Collects functional variants and assists users to find the functional roles of m6A variants. m6Avar permits researchers to search or browse: (i) m6A-associated genetic mutations (dbSNP), (ii) m6A-associated cancer somatic mutations (TCGA), (iii) disease related m6A-associated variants (GWAS and ClinVar), (iv) splicing sites affected by m6A-associated variants, (v) RNA binding protein affected by m6A-associated variants, and (vi) miRNA targeting and processing affected by m6A-associated variants.