A web tool to study the flexibility of nucleic acids, either isolated or bound to other molecules. NAFlex integrates a variety of analysis packages for mining nucleic acid trajectories. Analysis results are presented in several numerical and graphical formats. NAFlex also provides estimates of a number of NMR observables (see help for details), which can be used for either trajectory validation or for ab initio spectral predictions.
Offers an approach dedicated to the determination of temperature B-factor. RNAflex supplies a web platform that is a based only on RNA sequence information and combines support vector machine (SVM) models and sequence profiles. The method was tested on a dataset of 142 RNA structures. It generates a Pearson’s correlation coefficient (PCC) of 0.51 for the fivefold cross validation.
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