RNA thermometer detection software tools | Structure data analysis
RNA thermometers are temperature-sensitive RNAs that regulate gene expression. They are also known as RNA thermosensors and in general, they alter their secondary structure in response to temperature fluctuations.
Predicts the location of RNA thermometers using direct temperature simulations. RNAthermsw is a web server which analyses dotted figures generated as a result of a moving window that performs successive energy minimization folding predictions. The software performs two folding predictions by energy minimization inside the given window: the first with a default temperature and the second with a specified change in temperature that is intended to approximately simulate a heatshock or a cold-shock effect.
Predicts regions with high likelihood of temperature-induced structural changes. RNAtips is a web server which can be used to analyze the location of temperature-induced changes in the secondary structure of RNA and to compare such changes between two sequences of the same length. The software can be applied to a broad spectrum of research topics such as drug development, molecular diagnostic and disease prognosis, evolutionary mechanisms, ecology, investigation of climate change effects.