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ROAST

A statistically rigorous gene set test that allows for gene-wise correlation while being applicable to almost any experimental design. Instead of permutation, ROAST uses rotation, a Monte Carlo technology for multivariate regression. Since the number of rotations does not depend on sample size, ROAST gives useful results even for experiments with minimal replication. ROAST allows for any experimental design that can be expressed as a linear model, and can also incorporate array weights and correlated samples. ROAST is implemented as a function in the Bioconductor package limma.

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ROAST classification

ROAST specifications

Software type:
Package/Module
Restrictions to use:
None
Programming languages:
R
Stability:
Stable
Interface:
Command line interface
Operating system:
Unix/Linux, Mac OS, Windows
Computer skills:
Advanced
Maintained:
Yes

ROAST distribution

versioning

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No versioning.

Credits

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Publications

Institution(s)

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

Link to literature

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