Assists users for HD super-resolution imaging with arbitrary point-spread functions (PSFs). RoSE is an application that jointly recovers molecular position and brightness. It estimates the likelihood of fluorescence emission for individual blinking events, which enables molecules with overlapping images to be localized in the continuous domain and increases localization and photon-counting accuracy.
Department of Electrical and Systems Engineering, Washington University in St. Louis, MO, USA
RoSE funding source(s)
Supported by the National Science Foundation under grant number ECCS-1653777 and by the National Institute of General Medical Sciences of the National Institutes of Health under grant number R35GM124858.