Consists of a repository of gene orthologs. Roundup contains more than 1800 genomes from UniProtKB and over than 11 billion orthologs. Users can search for orthologs through two ways. The first, “Browse”, is a query that is a genome-centric search and retrieves all orthologs between one genome and a set of other genomes. The second query, “Retrieve”, finds all orthologs for all pairs of genomes in a set of genomes specified by the user.