Determines the functional sites of ncRNAs. Rsite2 employs RNA secondary structures to make its predictions. It provides users with the source codes and a web-server, simplifying the predictions of the functional sites of their ncRNAs. This tool was applied to RNAase P whose secondary structure and functional sites were experimentally identified. It identifies as functional sites the nucleotides locating within the extreme points in the distance curve derived from the secondary structure.
Department of Biomedical Informatics, Centre for Noncoding RNA Medicine, School of Basic Medical Sciences, Peking University, Beijing, China
Rsite2 funding source(s)
Supported by National Nature Science Foundation of China (Nos 91339106, 81422006), National Basic Research Program of China (2012CB517506), and National High Technology Research and Development Program of China (2014AA021102).