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Rsolnp specifications


Unique identifier OMICS_15890
Name Rsolnp
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 3.0, GNU General Public License version 2.0
Computer skills Advanced
Version 1.16
Stability Stable
stats, parallel, R(≥2.10.0), truncnorm
Source code URL
Maintained Yes




No version available



  • person_outline Alexios Ghalanoss <>

Rsolnp citations


On the testing of Hardy‐Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers

PMCID: 5813254
PMID: 29071737
DOI: 10.1002/gepi.22079

[…] coefficients. no closed form expressions for the ml estimators of the parameters were found. ml estimators were therefore obtained by maximizing the likelihood function numerically, using r‐package rsolnp (ghalanos & theussl, ). maximization respected the nonlinear constraint −min(pa,pb)/(1−min(pa,pb))≤ρm≤1 for males; the analogous constraint was used for females with ρm replaced by ρf. […]


Assessment of Weighted Quantile Sum Regression for Modeling Chemical Mixtures and Cancer Risk

PMCID: 4431483
PMID: 26005323
DOI: 10.4137/CIN.S17295

[…] the nonlinear function in equation , subject to the linear constraint ∑i=1cwi=1 and the bounds wi∈[0,1]. the nonlinear optimization was performed in r using the function solnp found in the package rsolnp. the algorithm employed belongs to the class of indirect solvers and implements the augmented lagrange multiplier method with a sequential quadratic programing interior algorithm., […]


Annotation of genomics data using bidirectional hidden Markov models unveils variations in Pol II transcription cycle

PMCID: 4300491
PMID: 25527639
DOI: 10.15252/msb.20145654

[…] these constraints define a non-convex optimization domain. still, powerful numerical solvers for concave functions exist. in our case, we used the ipopt solver (wächter & biegler, ) and rsolnp (version 1.14, transition probabilities might become very small or even 0, which may cause problems […]

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