RVS statistics

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Citations per year

Number of citations per year for the bioinformatics software tool RVS

Tool usage distribution map

This map represents all the scientific publications referring to RVS per scientific context
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Associated diseases


Popular tool citations

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RVS specifications


Unique identifier OMICS_20119
Name RVS
Alternative name Rare Variant Sharing
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 2.0
Computer skills Advanced
Version 1.3.1
Stability Stable
methods, stats, utils, testthat, BiocStyle, rmarkdown, knitr, snpStats, R(>=3.4.0), kinship2, gRain
Maintained Yes




No version available


  • person_outline Thomas Sherman
  • person_outline Alexandre Bureau

Additional information

Manual: http://bioconductor.org/packages/devel/bioc/manuals/RVS/man/RVS.pdf

Publication for Rare Variant Sharing

RVS citations


Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase

PMCID: 5355296
PMID: 28035074
DOI: 10.18632/oncotarget.14302

[…] herapy in an effort to fight Ebola, orthomyxoviruses (influenza), Middle East Respiratory Syndrome (MERS-CoV), the Hepatitis C virus (HCV), the cytomegalovirus (CMV), the respiratory syncytial virus (RVS), and rhabodviruses (rabies) (http://tamirbio.com/).Taking into account the large number of diseases with high social impact that are or can be treated with ONC, we have used microarray technology […]


Haplotype estimation for biobank scale datasets

Nat Genet
PMCID: 4926957
PMID: 27270105
DOI: 10.1038/ng.3583

[…] using other long-range phasing methods.In other work, we have shown that large and accurately phased haplotype reference panels can be used to help phase single sequenced samples. This approach uses rare variant sharing between the sequenced sample and the reference panel to efficiently select a set of template haplotypes to use within the HMM model. The Oxford Statistics Phasing Server allows us […]


Ribosome quality control is a central protection mechanism for yeast exposed to deoxynivalenol and trichothecin

BMC Genomics
PMCID: 4888481
PMID: 27245696
DOI: 10.1186/s12864-016-2718-y

[…] oxin response we marked the notoriously isolated multidrug sensitive mutants in our analysis (e.g. Table ; MDR). These belong to the CCR4-NOT complex (CCR4, POP2, VMS1), cytoskeleton and endocytosis (RVS161, RVS167, SAC6, VRP1, SLA1), vacuole (VMA8, VMA11, VMA13, VMA22), the cell wall integrity pathway (SLT2, BCK1), URE2 encoding a prion, the sterol desaturase encoded by ERG3 affecting membrane pe […]


Surfing waves of data in San Diego: sophisticated analyses provide a broad view of human genetic diversity

Genome Biol
PMCID: 4318178
PMID: 25651070
DOI: 10.1186/s13059-014-0562-4

[…] discussed results from the sequencing of five ancient British samples, remarkably found on the grounds of the Sanger Institute itself. Schiffels’ talk included new methods, based on inter-population rare-variant sharing patterns, that allow inference of very recent timescale events.Stephen Leslie (Murdoch Childrens Research Institute, Australia) used the hierarchical clustering algorithm fineSTRU […]


Demography and the Age of Rare Variants

PLoS Genet
PMCID: 4125085
PMID: 25101869
DOI: 10.1371/journal.pgen.1004528

[…] ations , , may make an important contribution to genetic susceptibility to disease –, and provide information about both demographic history, and fine-scale population structure , . While patterns of rare variant sharing are informative in themselves, knowing the age of the variants allows us to observe changes in structure over time, and thus to infer the dates of demographic events.Rare variants […]

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RVS institution(s)
Département de Médecine Sociale et Préventive, Université Laval, QC, Canada; Centre de recherche CERVO, QC, Canada; Office of Biostatistics, Food and Drug Administration, Silver Spring, MD, USA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA; Prime Health Clinic Jeddah, Riyadh, Saudi Arabia; Institute of Genetic Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Pediatrics, School of Medicine, University of Iowa, Iowa City, IA, USA; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Inherited Disease Research Branch, National Human Genome Research Institute, Baltimore, MD, USA
RVS funding source(s)
Supported by NIDCR grant R03-DE-02579.

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