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S4TE specifications

Information


Unique identifier OMICS_19755
Name S4TE
Alternative names Searching algorithm for Type-IV secretion system Effectors, Searching algorithm for Type-IV Effectors proteins
Software type Application/Script
Interface Command line interface
Restrictions to use Academic or non-commercial use
Programming languages Perl
Computer skills Advanced
Version 1.4
Stability Stable
Maintained Yes

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Maintainers


  • person_outline Damien Meyer
  • person_outline S4TE Team

Information


Unique identifier OMICS_19755
Name S4TE
Alternative names Searching algorithm for Type-IV secretion system Effectors, Searching algorithm for Type-IV Effectors proteins
Interface Web user interface
Restrictions to use Academic or non-commercial use
Computer skills Basic
Version 2.0
Stability Stable
Maintained Yes

Maintainers


  • person_outline Damien Meyer
  • person_outline S4TE Team

Publications for Searching algorithm for Type-IV secretion system Effectors

S4TE citations

 (5)
library_books

Comparative Genomics of the Zoonotic Pathogen Ehrlichia chaffeensis Reveals Candidate Type IV Effectors and Putative Host Cell Targets

2017
PMCID: 5263134
PMID: 28180111
DOI: 10.3389/fcimb.2016.00204

[…] r, mitochondrial, plasma membrane, endoplasmic reticulum, and cytoskeleton (Figure ). As described above, we predicted the subcellular localization in human host cell of E. chaffeensis T4Es using the S4TE algorithm (Table , Table ). Out of the 13 predicted T4Es of E. chaffeensis that interact with human proteins, eight (~60%) harbor at least one nuclear location signal (NLS). Interestingly, most o […]

library_books

Interactions “Candidatus Liberibacter solanacearum”—Bactericera cockerelli: Haplotype Effect on Vector Fitness and Gene Expression Analyses

2016
PMCID: 4899927
PMID: 27376032
DOI: 10.3389/fcimb.2016.00062

[…] The S4TE software predicted 23 type IV effector genes by using score 5 as threshold as shown in Table . Two genes were predicted with highest score at 8, CKC_RS05675 and CKC_RS00980, they encode hypotheti […]

library_books

Comparative Proteomic Profiling of Ehrlichia ruminantium Pathogenic Strain and Its High Passaged Attenuated Strain Reveals Virulence and Attenuation Associated Proteins

2015
PLoS One
PMCID: 4686967
PMID: 26691135
DOI: 10.1371/journal.pone.0145328

[…] nd VirD4, ). Manual reannotation of proteins allowed us to identify ER bacterial effectors homologous to A.phagocytophilum proteins, such as T4SS-secreted proteins AnkA (previously predicted in ER by S4TE software [] and detected in ERGvir []), Ank–B-C, Ats-1 and AprX proteins. We also identified a BAX inhibitor (BI)-1 like protein. Ats-1 and BI-1 like protein are known to interfere with apoptosis […]

library_books

Identification and Characterization of Anaplasma phagocytophilum Proteins Involved in Infection of the Tick Vector, Ixodes scapularis

2015
PLoS One
PMCID: 4560377
PMID: 26340562
DOI: 10.1371/journal.pone.0137237

[…] ructure and function of the E. coli T4SS []. Additionally, the preliminary analysis of A. phagocytophilum proteins present in tick salivary glands and/or high percentage infected tick cells using the S4TE software [] to identify candidate T4SS effectors suggested that Iron-binding protein (APH_0051), Peptidase (APH_1159) and HSP70 (APH_0346) harbor several characteristic features of proteins that […]

library_books

Proteomic Profiling of the Outer Membrane Fraction of the Obligate Intracellular Bacterial Pathogen Ehrlichia ruminantium

2015
PLoS One
PMCID: 4339577
PMID: 25710494
DOI: 10.1371/journal.pone.0116758

[…] proteins, we obtained a majority of 50S ribosomal subunits, as has been shown in Legionella []. Interestingly, one ribosomal protein we found in the OM fraction (ERGA_CDS_01640) has been predicted by S4TE software as a putative type IV effector []. Type IV effectors are proteins produced by pathogenic bacteria to manipulate host cell gene expression and other processes and have been shown to be cr […]

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S4TE institution(s)
CIRAD, UMR ASTRE, Petit-Bourg, Guadeloupe, France; ASTRE, Univ Montpellier, CIRAD, INRA, Montpellier, France; Université des Antilles, Pointe-à-Pitre, Guadeloupe, France
S4TE funding source(s)
Supported by UE, FEDER 2007–2013 [FED 1/1.4-30305] ‘Risk in animal and plant health’.

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