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SAPS specifications


Unique identifier OMICS_19712
Alternative name Statistical Analysis of Protein Sequences
Interface Web user interface
Restrictions to use None
Input data A protein sequence.
Input format GCG, FASTA, EMBL, GenBank, PIR, NBRF, PHYLIP, UnioProtKB, SwissProt
Computer skills Basic
Stability Stable
Source code URL
Maintained Yes

Additional information

SAPS citations


Modeling Hsp70/Hsp40 interaction by multi scale molecular simulations and coevolutionary sequence analysis

PMCID: 5519331
PMID: 28498104
DOI: 10.7554/eLife.23471.040

[…] tacts (; ). More recently, solution PRE-NMR experiments identified an alternative highly dynamic interface between ADP-bound DnaK and DnaJ ().Here we relied on both multi-scale molecular modeling and statistical analysis of protein sequences to shed light on the Hsp70/Hsp40 interactions. By combining these complementary techniques, we propose a structural model of the binding of bacterial DnaK/Dna […]


CoagVDb: a comprehensive database for coagulation factors and their associated SAPs

PMCID: 4506595
PMID: 26187044
DOI: 10.1186/s40659-015-0028-5

[…] with their biophysical characteristic in the native and mutant state of numerous proteins [–]. We calculated the composition of each amino acid in corresponding coagulation factor protein sequence by Statistical Analysis of Protein Sequences []. For this analysis, we submitted the individual protein FASTA sequence as an input file. […]


Computational Biophysical, Biochemical, and Evolutionary Signature of Human R Spondin Family Proteins, the Member of Canonical Wnt/β Catenin Signaling Pathway

Biomed Res Int
PMCID: 4172882
PMID: 25276837
DOI: 10.1155/2014/974316

[…] type and protein sequence properties, such as amino acid composition percentage, high scoring hydrophobic segments, and tandem and periodic repeats of structure data of the human (Rspo)s, we used the statistical analysis of protein sequences (SAPS) [], which is one of the most significant tools to bring out the details about protein sequence properties.For the study of the secondary structural asp […]


Selection and demographic history shape the molecular evolution of the gamete compatibility protein bindin in Pisaster sea stars

Ecol Evol
PMCID: 4063459
PMID: 24967076
DOI: 10.1002/ece3.1042

[…] rsal plasmid primers. We characterized some general features of the bindin-coding sequence structure by searching for peptide cleavage sites in ProP ( We used the statistical analysis of protein sequences (SAPS; package to estimate the molecular weight and amino acid composition of the predicted mature bindin molecule […]


First characterization of Plasmodium vivax liver stage antigen (PvLSA) using synthetic peptides

PMCID: 3925417
PMID: 24520895
DOI: 10.1186/1756-3305-7-64

[…] vivax Korean isolates, and 4,521 nucleotides were predicted to encode a polypeptide consisting of 1,507 amino acid residues. The molecular weight of the mature protein was 173.4 kDa, as calculated by Statistical Analysis of Protein Sequences (SAPS, To select peptide candidates with high antigenicity, we used the following B-cell epitope mapping programs […]


Evolution and Structure Based Computational Strategy Reveals the Impact of Deleterious Missense Mutations on MODY 2 (Maturity Onset Diabetes of the Young, Type 2)

PMCID: 3936290
PMID: 24578721
DOI: 10.7150/thno.7473

[…] To measure the effects of deleterious amino acid substitutions on the GCK protein, we determined the amino acid composition of the protein in both its native and mutated states using Statistical Analysis of Protein Sequences . : Figure S4 shows the amino acid composition of the native GCK protein, which contains 465 amino acid residues. Of these, the occurrence of leucine was foun […]


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