SAPTA statistics

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Citations per year

Number of citations per year for the bioinformatics software tool SAPTA

Tool usage distribution map

This map represents all the scientific publications referring to SAPTA per scientific context
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Associated diseases


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SAPTA specifications


Unique identifier OMICS_10624
Alternative name Scoring Algorithm for Predicting TALEN Activity
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Gang Bao

Publication for Scoring Algorithm for Predicting TALEN Activity

SAPTA citations


TALEN based HPV E7 editing triggers necrotic cell death in cervical cancer cells

Sci Rep
PMCID: 5511212
PMID: 28710417
DOI: 10.1038/s41598-017-05696-0

[…] biological activity. The second criterion is to screen for unique areas in the genome in order to minimize off-target effects. Taken these criteria into consideration, TALEN pairs were screened using SAPTA software and the region selected was such way that it targeted at position 44 which was in the start region of Exon I of E7 (Fig. ). This TALEN pair had 19 binding sites on either side with a sp […]


Testing the causality between CYP9M10 and pyrethroid resistance using the TALEN and CRISPR/Cas9 technologies

Sci Rep
PMCID: 4837413
PMID: 27095599
DOI: 10.1038/srep24652

[…] TALENs, TALEN9M10-3L and -R, targeting the first exon of CYP9M10 in JPP (Genbank ID: AB332027) were designed with the SAPTA algorithm and constructed using the PC assembly described above. Frame-shifting in this exon was expected to disrupt the gene function because critical protein domains such as a heme-binding reg […]


Nuclease Target Site Selection for Maximizing On target Activity and Minimizing Off target Effects in Genome Editing

PMCID: 4786925
PMID: 26750397
DOI: 10.1038/mt.2016.1

[…] ng of TALEN pairs. The E-TALEN webtool incorporates a scoring algorithm for ranking potential TALENs, but this scoring system was not experimentally validated. The second-generation TALEN design tool SAPTA (Scoring Algorithm for Predicting TALEN Activity) uses improved guidelines for TALEN design based on rules derived from experimentally testing 205 individual TALEN monomers. The SAPTA algorithm […]


Context influences on TALE–DNA binding revealed by quantitative profiling

Nat Commun
PMCID: 4467457
PMID: 26067805
DOI: 10.1038/ncomms8440

[…] with greater specificity, which could be interpreted as guidelines for TALE design (). Interestingly, some of these guidelines would contradict published guidelines that were developed as part of the SAPTA tool for designing more active TALEN pairs. For example, although we predict that A-runs can be targeted with high specificity by TALE monomers, SAPTA predicts that TALENs targeting A-runs will […]

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SAPTA institution(s)
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA
SAPTA funding source(s)
National Institutes of Health (NIH Nanomedicine Development Center Award, PN2EY018244); National Science Foundation Graduate Research Fellowship (DGE-1148903)

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