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Screening for Non-Acceptable Polymorphisms SNAP

A neural-network based tool to be used for the evaluation of functional effects single amino acid substitutions in proteins. SNAP utilizes various biophysical characteristics of the substitution, as well as evolutionary information, some predicted—or when made available observed—structural features, and possibly annotations, to predict whether or not a mutation is likely to alter protein function (in either direction: gain or loss). SNAP identifies over 80% of the non-neutral mutations at 77% accuracy and over 76% of the neutral mutations at 80% accuracy at its default threshold.

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SNAP classification

SNAP specifications

Web user interface
Input data:
A protein sequence
Computer skills:
Restrictions to use:
Input format:


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Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA

Link to literature

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