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Scrubber specifications


Unique identifier OMICS_29464
Name Scrubber
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Windows
Computer skills Advanced
Version 2.0c
Stability Stable
Maintained Yes




No version available


  • person_outline Scrubber Team

Scrubber citations


A General Strategy for Discovery of Inhibitors and Activators of RING and U box E3 Ligases with Ubiquitin Variants

Mol Cell
PMCID: 5655547
PMID: 29053960
DOI: 10.1016/j.molcel.2017.09.027

[…] ith the built-in equation formula (non-linear regression curve). For SPR assays, the data were analyzed by steady-state affinity analysis using Biacore T200 BIAevaluation software (GE Healthcare) and Scrubber2 (BioLogic Software); data are presented as mean ± SEM in and the number of replicates (n) for each KD measurement is two (). For D, gels were exposed to a storage phosphor screen (Fujifilm […]


Astrocyte Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation

PMCID: 5663462
PMID: 29024665
DOI: 10.1016/j.neuron.2017.09.053

[…] a buffer injection was performed, allowing for double referencing of the binding responses (). No regeneration was performed after buffer injections. Equilibrium binding analysis was performed using Scrubber 2.0 (BioLogic Software, and data was fitted to a 1:1 Langmuir binding model in Prism 6 (Graphpad). Dissociation constants of GluA1-Fab and Mut-Fab and the maximum […]


A fully humanized IgG like bispecific antibody for effective dual targeting of CXCR3 and CCR6

PLoS One
PMCID: 5584921
PMID: 28873441
DOI: 10.1371/journal.pone.0184278

[…] and hCXCR3 as well as an equimolar mixture of hCXCR3/hCCR6 peptides were injected simultaneously in the horizontal direction (1 μM final concentration). All SPR binding data were processed using the Scrubber-Pro software package ( […]


Structural Mechanism for Modulation of Synaptic Neuroligin Neurexin Signaling by MDGA Proteins

PMCID: 5563082
PMID: 28817804
DOI: 10.1016/j.neuron.2017.07.040

[…] MDGA1ECTO and MDGA2ECTO, the surfaces were regenerated using consecutive 30 s injections of 10 mM Tris pH 7.4, 100 mM L-Arginine/L-Glutamate, 1M NaCl. Equilibrium binding analysis was performed using Scrubber 2.0 (BioLogic Software) and data was fitted to a 1:1 Langmuir binding model in Prism 6 (Graphpad). […]


Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus

PMCID: 4427200
PMID: 25945581
DOI: 10.1107/S1399004715004228

[…] probed for binding as a double-negative control for both AroD and SaBADH. Binding responses, measured as resonance units (RU), were double referenced and fitted with the Langmuir binding model using SCRUBBER2 available at […]


Advantages of the Phosphatidylserine Recognizing Peptide PSP1 for Molecular Imaging of Tumor Apoptosis Compared with Annexin V

PLoS One
PMCID: 4372538
PMID: 25803297
DOI: 10.1371/journal.pone.0121171

[…] rface was regenerated after each association and dissociation cycle by injecting 10 mM EDTA for 20 s, followed by 50 mM NaOH for 10 s. The interaction of the ligand and the analyte was analyzed using Scrubber 2 Biologic software ( The binding kinetics was assessed by determining the association (kon), dissociation (koff), and equilibrium (KD) constants. […]


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