SDRS statistics

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Citations per year

Number of citations per year for the bioinformatics software tool SDRS
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Tool usage distribution map

This map represents all the scientific publications referring to SDRS per scientific context
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Associated diseases

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Popular tool citations

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SDRS specifications

Information


Unique identifier OMICS_33400
Name SDRS
Alternative name Sigmoidal Dose Response Search
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Perl
Computer skills Advanced
Version 0.11
Stability Stable
Maintained Yes

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Versioning


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Maintainers


  • person_outline Rui-Ru Ji
  • person_outline Robert Bruccoleri

Publication for Sigmoidal Dose Response Search

SDRS citations

 (2)
library_books

Genome wide dose dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super enhancers

2017
Nucleic Acids Res
PMCID: 5829637
PMID: 29240919
DOI: 10.1093/nar/gkx1225

[…] ted gene lengths. Using FStitch calls, we calculated the total acetylation signal for both H3K9ac and –K27ac along the gene bodies for each of the nine corresponding ChIP-seq experiments and used the Sigmoidal Dose Response Search algorithm (SDRS) with a P = 0.05 cutoff (). This approach allowed us to effectively assign each gene a largazole dosage sensitivity for both H3K9ac and –K27ac changes (F […]

library_books

SDRS—an algorithm for analyzing large scale dose–response data

2011
Bioinformatics
PMCID: 3187656
PMID: 21865301
DOI: 10.1093/bioinformatics/btr489

[…] Our implementation of the SDRS algorithm includes a typical sigmoidal dose–response model for one-site compound:target interaction, where Y is the assay readout value, X is the dose and the four unknown parameters correspond […]


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SDRS institution(s)
Department of Applied Genomics, Bristol-Myers Squibb, Princeton, NJ, USA; Department of Lead Evaluation and Mechanistic Chemistry, Bristol-Myers Squibb, Princeton, NJ, USA; Congenomics, Glastonbury, CT, USA
SDRS funding source(s)
Supported by Bristol-Myers Squibb.

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