SDRS specifications


Unique identifier OMICS_33400
Alternative name Sigmoidal Dose Response Search
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Perl
Computer skills Advanced
Version 0.11
Stability Stable
Maintained Yes




No version available


  • person_outline Rui-Ru Ji
  • person_outline Robert Bruccoleri

Publication for Sigmoidal Dose Response Search

SDRS citations


Genome wide dose dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super enhancers

Nucleic Acids Res
PMCID: 5829637
PMID: 29240919
DOI: 10.1093/nar/gkx1225

[…] ted gene lengths. Using FStitch calls, we calculated the total acetylation signal for both H3K9ac and –K27ac along the gene bodies for each of the nine corresponding ChIP-seq experiments and used the Sigmoidal Dose Response Search algorithm (SDRS) with a P = 0.05 cutoff (). This approach allowed us to effectively assign each gene a largazole dosage sensitivity for both H3K9ac and –K27ac changes (F […]


SDRS—an algorithm for analyzing large scale dose–response data

PMCID: 3187656
PMID: 21865301
DOI: 10.1093/bioinformatics/btr489

[…] the best model, but do not provide a means that can be integrated in downstream analyses such as the characterization of transcriptome response ().) recently described a grid search-based algorithm, Sigmoidal Dose Response Search (SDRS), for identifying transcripts that exhibited sigmoidal dose-response to the treatments of kinase inhibitors. Since the SDRS algorithm is generic and can be expande […]

SDRS institution(s)
Department of Applied Genomics, Bristol-Myers Squibb, Princeton, NJ, USA; Department of Lead Evaluation and Mechanistic Chemistry, Bristol-Myers Squibb, Princeton, NJ, USA; Congenomics, Glastonbury, CT, USA
SDRS funding source(s)
Supported by Bristol-Myers Squibb.

SDRS reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review SDRS