SDRS specifications

Information


Unique identifier OMICS_33400
Name SDRS
Alternative name Sigmoidal Dose Response Search
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Perl
Computer skills Advanced
Version 0.11
Stability Stable
Maintained Yes

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Versioning


No version available

Maintainers


  • person_outline Rui-Ru Ji
  • person_outline Robert Bruccoleri

Publication for Sigmoidal Dose Response Search

SDRS citations

 (2)
library_books

Genome wide dose dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super enhancers

2017
Nucleic Acids Res
PMCID: 5829637
PMID: 29240919
DOI: 10.1093/nar/gkx1225

[…] ted gene lengths. Using FStitch calls, we calculated the total acetylation signal for both H3K9ac and –K27ac along the gene bodies for each of the nine corresponding ChIP-seq experiments and used the Sigmoidal Dose Response Search algorithm (SDRS) with a P = 0.05 cutoff (). This approach allowed us to effectively assign each gene a largazole dosage sensitivity for both H3K9ac and –K27ac changes (F […]

library_books

SDRS—an algorithm for analyzing large scale dose–response data

2011
Bioinformatics
PMCID: 3187656
PMID: 21865301
DOI: 10.1093/bioinformatics/btr489

[…] the best model, but do not provide a means that can be integrated in downstream analyses such as the characterization of transcriptome response ().) recently described a grid search-based algorithm, Sigmoidal Dose Response Search (SDRS), for identifying transcripts that exhibited sigmoidal dose-response to the treatments of kinase inhibitors. Since the SDRS algorithm is generic and can be expande […]

SDRS institution(s)
Department of Applied Genomics, Bristol-Myers Squibb, Princeton, NJ, USA; Department of Lead Evaluation and Mechanistic Chemistry, Bristol-Myers Squibb, Princeton, NJ, USA; Congenomics, Glastonbury, CT, USA
SDRS funding source(s)
Supported by Bristol-Myers Squibb.

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