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Specificity-determining sites (SDS) are the key positions of a protein family that show a specific conservation of amino acids, related to the subfamily members of that family. SDS play crucial role in developing functional variation within the protein family during the course of evolution. Thus, it is important to identify SDS to understand the evolutionary process of diversification of biological functions within a protein family. A wide range of computational tools have been designed to detect such SDS.
(Chakraborty and Chakrabarti 2015) A survey on prediction of specificity-determining sites in proteins. Brief Bioinform.