Sealer pipeline

Sealer specifications


Unique identifier OMICS_09432
Name Sealer
Software type Package/Module
Interface Command line interface
Restrictions to use Academic or non-commercial use
Operating system Unix/Linux
Programming languages C++
Computer skills Advanced
Stability Stable
Requirements Google sparsehash
Maintained Yes


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  • person_outline Inanc Birol <>

Publication for Sealer

Sealer IN pipelines

PMCID: 5347234
PMID: 28280014
DOI: 10.1128/genomeA.00022-17

[…] the sequences from the microbe, the reads were down-sampled to 400 mb, thereby reducing sequences originating from relatively minor species, and assembled using velvet, followed by gap-closing with sealer (4, 5). the resulting draft genome of strain emtcatb1 is 1.84 mb (g+c content, 67.2%) contained in a single circular scaffold with no gap, representing a circular chromosome. the scaffold […]

PMCID: 5597760
PMID: 28912319
DOI: 10.1128/genomeA.00963-17

[…] miseq reads using unicycler (11). the assembly was polished with unicycler_polish using all sequence reads and scaffolded with links v1.8.5 (12) using nanopore reads. assembly gaps were closed with sealer v1.5.2 using miseq reads exclusively (13). the resulting assembly was aligned against other m. chimaera genomes using mauve 2.3.1 (14). genomic features were identified and annotated using […]

Sealer institution(s)
Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

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