Natural products of bacteria and fungi are the most important source for antimicrobial drug leads. For decades, such compounds were exclusively found by chemical/bioactivity-guided screening approaches. The rapid progress in sequencing technologies only recently allowed the…
IMG-ABC
Data

IMG-ABC Integrated Microbial Genomes-Atlas of Biosynthetic gene Clusters

Offers experimentally verified and predicted biosynthetic gene clusters (BCs).…

Offers experimentally verified and predicted biosynthetic gene clusters (BCs). IMG-ABC database contains more than 730000 BCs in 40034 isolate microbial genomes and more than 310000 BCs in 2416…

SEARCHPKS
Web

SEARCHPKS

Facilitates easy identification of various polyketide synthase (PKS) domains…

Facilitates easy identification of various polyketide synthase (PKS) domains and modules from a given polypeptide sequence. SEARCHPKS is a software for detection and analysis of PKS domains in a…

PRISM
Web

PRISM PRediction Informatics for Secondary Metabolomes

A computational resource for the identification of biosynthetic gene clusters,…

A computational resource for the identification of biosynthetic gene clusters, prediction of genetically encoded nonribosomal peptides and type I and II polyketides, and bio- and cheminformatic…

NP.searcher
Desktop
Web

NP.searcher Natural products search engine

Scans rapidly microbial genomes for secondary metabolite biosynthetic gene…

Scans rapidly microbial genomes for secondary metabolite biosynthetic gene clusters, and output candidate nonribosomal peptide and polyketide natural products in SMILES format, enabling immediate…

NRPSsp
Desktop
Web

NRPSsp Non-Ribosomal Peptide Synthase substrate predictor

Applies a new approach in the areas of, the prediction based on HMM, enlarged…

Applies a new approach in the areas of, the prediction based on HMM, enlarged training sets applying mining techniques, the regular update of its database and its design for the functional analysis…

CLUSEAN
Desktop

CLUSEAN CLUster SEquence ANalyzer

Helps to annotate and analyze such gene clusters. CLUSEAN integrates standard…

Helps to annotate and analyze such gene clusters. CLUSEAN integrates standard analysis tools, like BLAST and HMMer, with specific tools for the identification of the functional domains and motifs in…

MIDDAS-M
Web

MIDDAS-M

A motif-independent de novo detection algorithm for secondary metabolite…

A motif-independent de novo detection algorithm for secondary metabolite biosynthetic (SMB) gene clusters. MIDDAS-M enables the comprehensive exploration of functional SMB genes in fungal genomes by…

PKSIIIexplorer
Web

PKSIIIexplorer

A web server based on 'transductive support vector machine' that…

A web server based on 'transductive support vector machine' that allows fast and reliable prediction of Type III polyketide synthase proteins. Users can submit their protein sequences in…

r-CSDB
Data

r-CSDB recombinant ClustScan database

Contains information about predicted recombinants between polyketide synthases…

Contains information about predicted recombinants between polyketide synthases (PKS clusters). The recombinants are generated by modeling homologous recombination and are associated with annotation…

SMURF
Web

SMURF Secondary Metabolite Unique Regions Finder

A web-based tool that finds secondary metabolite biosynthesis genes and…

A web-based tool that finds secondary metabolite biosynthesis genes and pathways in fungal genomes. The predictions are based on PFAM and TIGRFAM domain content as well as on a gene's…

CSDB
Data

CSDB ClustScan database

Contains highly annotated descriptions of 170 clusters. CSDB has a hierarchical…

Contains highly annotated descriptions of 170 clusters. CSDB has a hierarchical organization, which allows easy extraction of DNA and protein sequences of polypeptides, modules, and domains as well…

ClusterMine360
Data

ClusterMine360

A database of microbial polyketide and non-ribosomal peptide gene clusters.…

A database of microbial polyketide and non-ribosomal peptide gene clusters. ClusterMine360 takes advantage of crowd-sourcing by allowing members of the community to make contributions while…

DoBISCUIT
Data

DoBISCUIT Database of BIoSynthesis clusters CUrated and InTegrated

A literature-based, manually curated database of gene clusters for secondary…

A literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. DoBISCUIT integrates the latest literature information and provides standardized…

SBSPKS
Web

SBSPKS

A webserver for carrying out sequence and structure based analysis of…

A webserver for carrying out sequence and structure based analysis of Polyketide Synthases, an important family of multifunctional megasynthases involved in the biosynthesis of a variety of…

antiSMASH
Desktop
Web

antiSMASH antibiotics & Secondary Metabolite Analysis Shell

A comprehensive pipeline capable of identifying biosynthetic loci covering the…

A comprehensive pipeline capable of identifying biosynthetic loci covering the whole range of known secondary metabolite compound classes (polyketides, non-ribosomal peptides, terpenes,…

ClustScan-Profe…
Desktop

ClustScan-Professional

An integrated suite of computer programs that take a "top down"…

An integrated suite of computer programs that take a "top down" approach to the annotation of gene clusters encoding thiotemplate modular systems (TMS). ClustScan-Professional can analyse…

PKMiner
Data

PKMiner

A comprehensive computational analysis of type II PKSs and their gene clusters…

A comprehensive computational analysis of type II PKSs and their gene clusters in actinobacterial genomes. PKMiner is useful for research in the discovery of novel bacterial aromatic polyketides.

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