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SEGreg specifications


Unique identifier OMICS_25847
Name SEGreg
Restrictions to use None
Database management system MySQL
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes


  • person_outline An-Yuan Guo

Additional information

Publication for SEGreg

SEGreg citations


Using an Event History with Risk Free Model to Study the Genetics of Alcoholism

Sci Rep
PMCID: 5434012
PMID: 28512340
DOI: 10.1038/s41598-017-01791-4

[…] enetic association study, although some software (e.g., PENETRANCE in MENDEL) can handle age of onset for penetrance estimation and the subsequent association analyses, and some other software (e.g., SEGREG in S.A.G.E.) can jointly analyze the susceptibility and age of onset for segregation analyses. Hence, we only selected independent founders from the 14 pedigrees. Second, the effects of ethnic […]


Whole genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic trait mapping

PMCID: 5200897
PMID: 27874836
DOI: 10.1242/dmm.027037

[…] an EDR haplotype is still present at a given locus in the reference population and which accounts for all random loss of alleles during segregation and due to genetic drift, was calculated with the ‘segreg’ function of PEDIG () as: (4)where ri is the fraction of an EDR's alleles presumed to have been retained in the population (). […]


Improvement in detection of minor alleles in next generation sequencing by base quality recalibration

BMC Genomics
PMCID: 4769523
PMID: 26920804
DOI: 10.1186/s12864-016-2463-2

[…] We first use simulation data for the comparison of SEGREG with other approaches. Although any simulation is a simplification of real data, it has the advantage over real data in that all sequence errors and true minor alleles are known beforehand, whe […]


Do Mitochondria Limit Hot Fish Hearts? Understanding the Role of Mitochondrial Function with Heat Stress in Notolabrus celidotus

PLoS One
PMCID: 3665896
PMID: 23724026
DOI: 10.1371/journal.pone.0064120
call_split See protocol

[…] were analyzed using a repeated measures ANOVA followed by a post hoc Tukey test with a significance level of P≤0.05. In experimental fish, ABT was determined by segmented linear regression using the SegReg program ( R2 was computed from the sum of the squares of the distances of the points from the best-fit line determined by nonlinear regression using Prism5®. The plasma metab […]


Ontogenetic Development of Weberian Ossicles and Hearing Abilities in the African Bullhead Catfish

PLoS One
PMCID: 3075255
PMID: 21533262
DOI: 10.1371/journal.pone.0018511
call_split See protocol

[…] with the software SPSS 17.0 (SPSS Inc., Chicago, Illinois). When datapoints showed two different distribution patterns, segmented linear regressions and breakpoints were calculated using the software SegReg (R. J. Oosterbaan, Wageningen, The Netherlands).The study protocol was approved by the Austrian Federal Ministry of Science and Research, permit number GZ 66.006/0023-II/10b/2008. […]


Ontogenetic development of auditory sensitivity and sound production in the squeaker catfish Synodontis schoutedeni

BMC Biol
PMCID: 2824629
PMID: 20113466
DOI: 10.1186/1741-7007-8-10
call_split See protocol

[…] (SPSS Inc., Chicago, IL, USA). If it was evident that data points in a graph showed two different distribution patterns, segmented linear regressions and breakpoints were calculated with the software SegReg (R. J. Oosterbaan, Wageningen, The Netherlands). […]


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SEGreg institution(s)
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Molecular Biophysics of the Ministry of Education, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
SEGreg funding source(s)
Supported by funding from the National Natural Science Foundation of China (No. 31471247 and 31771458) and Open Project funded by Key laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing (2017 Open Project-6).

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