Highlights the affinity and selectivity of compounds in the HMS-LINCS collection, for a gene of interest. SelectivitySelectR allows users to see the mean affinity and selectivity for all LINCS compounds with a known affinity for their target. It is composed of three steps: (1) selection of a target of interest and binding criteria, (2) selection of a region in the main plot with compounds of interest, and (3) selection of three compounds in the bottom table and visualization of their known binding affinities.
HMS LINCS and Druggable Genome Centers, Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA; Department of Systems Biology, Harvard Medical School, Boston, MA, USA; Division of Biostatistics and Bioinformatics, Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA; Novartis Institutes for BioMedical Research Inc., Cambridge, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
SelectivitySelectR funding source(s)
Supported by NIH grants U54-HL127365, U24-DK116204, U54-HL127624 and by the Novartis Institutes for BioMedical Research.