Contains a secure, de-identified, web-accessible repository of genomic variants. SPHINX is a resource for eMERGE-PGx. Sequence variants determined from PGRNseq on all enrolled eMERGE-PGx participants will be available to the public via SPHINX in aggregate forms. Due to the risk of possible patient re-identification using demographic and clinical data, this database includes important privacy safeguards.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Vanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA; [etc.]
SPHINX funding source(s)
This work was supported by U01HG006828 (Cincinnati Children’s Hospital Medical Center/Harvard); U01HG006830 (Children’s Hospital of Philadelphia); U01HG006389 (Essentia Institute of Rural Health); U01HG006382 (Geisinger Clinic); U01HG006375 (Group Health Cooperative and the University of Washington); U01HG006379 (Mayo Clinic).); U01HG006380 (Icahn School of Medicine at Mount Sinai); U01HG006388 (Northwestern University); U01HG006378 (Vanderbilt University); U01HG006385 (Vanderbilt serving as the Coordinating Center); the Deep Resequencing Resources of the Pharmacogenomic Research Network: U01 HL069757, U19 GM61388, and U01 GM097119; grant U01HG004438; grant (HL069757); the NHGRI, 5U01HG006507; Mayo Clinic Center for Individualized Medicine and National Institutes of Health grants U19 GM61388 (The Pharmacogenomics Research Network), R01 GM28157, U01 HG005137, R01 CA138461, and R01 AG034676 (The Rochester Epidemiology Project); the Pharmacogenomics of Arrhythmia Therapy PGRN site grant from the National Institute of General Medical Sciences and the National Heart Lung and Blood Institute (U19 HL65262).