Humans routinely solve problems of immense computational complexity by intuitively forming simple, low-dimensional heuristic strategies. Citizen science (or crowd sourcing) is a way of exploiting this ability by presenting scientific research problems to non-experts. 'Gamification'--the application of game elements in a non-game context--is an effective tool with which to enable citizen scientists to provide solutions to research problems.
Allows easy, real-time, direct manipulation of protein structures. Foldit gives access to the extensive power of Rosetta computations. It provides added functionality to Rosetta like electron density and contact map visualizations or rigid body transformation controls. The software allows to construct template-based modelling thank to multiple sequence alignment tools integrated in. In addition, Foldit provides an accessible graphical structure manipulation interface coupled to the powerful Rosetta energy function and sampling methods.
Presents the RNA design problem as a set of puzzles. EteRNA is a scientific game that combines an interactive interface for modeling biomolecules with a remote wet laboratory experimental pipeline. Participants use an interactive sequence design interface to design RNA sequences that fold into target secondary structures. The interface visualizes each nucleotide with yellow, blue, red, and green circular symbols representing adenine, uracil, guanine, and cytosine, respectively.
Aims to compute high-quality alignments of a set of orthologous promoter regions from different vertebrate species. Phylo is a citizen computing framework for local improvement of multiple sequence alignment. As in any alignment, the goal of this scientific game is to move the blocks in order to find a configuration that maximizes conservation across columns while minimizing the number of gaps. The game also displays a phylogenetic tree for the set of sequences considered, with each species being represented by an avatar.
Offers an artificial intelligence (AI) to reduce the amount of human effort required for 3D reconstruction of neurons. EyeWire is based on a deep convolutional network (DCN). It was extended to images obtained using conventional staining techniques that mark intracellular organelles, in which synapses are clearly visible. This technique enables a true connection analysis that goes beyond the contact and co-stratification analyses employed.
Aims to catalog gene-disease associations that are well-established in the literature but not yet reflected in structured annotation databases. Dizeez is a multiple-choice quiz where the player is presented with a disease drawn from the Human Disease Ontology and a multiple-choice selector with five genes, only one of which has prior evidence linking it to the Clue disease. The results from Dizeez provides evidence that online games can be used to help address the growing challenge of structured gene annotation.
Provides help to tap into this hidden resource for biomedical discovery. The Cure is a game that aims to translate the knowledge of the players, along with their ability to process textual information, into a ranked list of genes for use in the development of predictors for breast cancer prognosis. This translation is enacted when the players select genes in the game.
Provides high-throughput access to biological knowledge and reasoning through online games. Through the gene annotation game GenESP, players can contribute their knowledge of gene function and disease relevance to a new kind of public gene annotation database.