Sherlock specifications


Unique identifier OMICS_04410
Name Sherlock
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Xin He <>

Publication for Sherlock

Sherlock in publications

PMCID: 5940825
PMID: 29739930
DOI: 10.1038/s41467-018-03621-1

[…] based on colocalization of eqtl and gwas signals. colocalized signals provide evidence of possible causal relationship between the target gene of an eqtl and the complex trait. these include rtc, sherlock, coloc, and more recently ecaviar and enloc., here we derive a mathematical expression that allows us to compute the results of predixcan without the need to use individual-level data, […]

PMCID: 5851982
PMID: 29540662
DOI: 10.1038/s41398-018-0114-x

[…] predicted the plausible candidate causal genes for schizophrenia at genome-wide level. we utilized different approaches and strategies to predict causal genes for schizophrenia, including sherlock, smr, dapple, prix fixe, netwas, and depict. by integrating the results from different prediction approaches, we identified six top candidates that represent promising causal genes […]

PMCID: 5826945
PMID: 29483533
DOI: 10.1038/s41467-018-03247-3

[…] example, a lbf of 5.64 means that the interested gene is more likely (281 times, (exp(5.64) = 281)) to be associated with schizophrenia than the null hypothesis (no association). for a given gene, sherlock first identifies all snps that are associated with the expression of this gene (these snps were called esnps). sherlock then scores each esnp based on the association significance […]

PMCID: 5769240
PMID: 29335020
DOI: 10.1186/s40246-018-0132-z

[…] the disease and the genetic control of gene expression.fig. 2, we integrated the nominally significant cis-eqtls (p < 10−3) and trans-eqtls (p < 10−6) with prior gwas using the bayesian method sherlock [], seeking genes with collective associations across the significant and sub-threshold gwas results. the 438,536 snps common to the eqtl, gwas, and gwas permutation data were the basis […]

PMCID: 5411756
PMID: 28334860
DOI: 10.1093/hmg/ddx061

[…] , known to cause familial epilepsy syndromes or epileptic encephalopathies, might also play a role in the development of sporadic focal epilepsy., analysis of the epilepsy gwas and eqtl results using sherlock (), a tool which detects disease genes by integrating gwas and eqtl data, corroborated the association between ttc21b and epilepsy (log bayes factor = 5.45, p-value = 1.7 x 10−5, fdr = 0.01). […]

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Sherlock institution(s)
Hao Li Laboratory, University of California, San Francisco, San Francisco, CA, USA

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