SHIELD specifications

Information


Unique identifier OMICS_09648
Name SHIELD
Alternative name Shared Harvard Inner Ear Laboratory Database
Restrictions to use None
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Maintainer


  • person_outline David P. Corey

Publication for Shared Harvard Inner Ear Laboratory Database

SHIELD citations

 (2)
library_books

Identification of sensory hair cell transcripts by thiouracil tagging in zebrafish

2015
BMC Genomics
PMCID: 4619078
PMID: 26494580
DOI: 10.1186/s12864-015-2072-5

[…] ese 21 putative hair cell-enriched transcripts, we identified a homologous mouse gene by either querying the Ensembl database, or by BLASTP similarity. We used this homology information to search the Shared Harvard Inner-ear Laboratory Database (SHIELD), a repository for an RNA sequencing dataset derived from FAC-sorted mouse hair cells [, ]. We found that 16 of the 18 mouse homologs had detectabl […]

library_books

Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness

2013
PLoS One
PMCID: 3575478
PMID: 23441200
DOI: 10.1371/journal.pone.0056520

[…] d to sensory and non-sensory cells . Another analysis confirmed low levels of Diap3 expression close to the threshold of detection in both sensory and non-sensory cells of the cochlea from E16 to P7 (Shared Harvard Inner-Ear Laboratory Database (SHIELD); https://shield.hms.harvard.edu/index.html). However, despite severe hearing loss at 24 weeks of age, both lines of Diap3-overexpressing transgeni […]

SHIELD institution(s)
Department of Pathology, Brigham and Women’s Hospital, Rutgers University, Piscataway, NJ, USA; Harvard Medical School Center for Hereditary Deafness, Rutgers University, Piscataway, NJ, USA; Department of Neurobiology, Rutgers University, Piscataway, NJ, USA; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA
SHIELD funding source(s)
The National Institute on Deafness and Other Communication Disorders at the National Institutes of Health grants (R01-DC000304, R01-DC002281 and R03-DC013866); The Hearing Health Foundation (Emerging Research Grant)

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